The NKF KEEP is the world's only sustainable chronic disease screening program. Its success is attributable in part to the continued dedication and commitment of stakeholders (NKF, local affiliates, and academic community), but also to a unique set of methods that balance detail with simplicity and place efficiency at a premium. The CKD-EPI equation appears to be an incremental refinement in the screening of large populations for CKD. It works to classify fewer participants with CKD based on the eGFR cutoff of 60 mL/min/1.7 3m 2; however, appropriately, participants who are classified with CKD appear to be at higher risk of morbidity and mortality. Using this equation appears to have little impact on what is at present a low awareness of CKD in those who are discovered to have it. Finally, because diabetes and CKD share mutual risk factors, screening for both diabetes and CKD makes considerable sense in large chronic disease screening programs outside KEEP. We look forward to future advancements in KEEP and anticipate that its efforts will continue to shape what we know about common chronic diseases in the hopes of preventing their further spread.