TY - JOUR
T1 - Nanoscale assemblies and their biomedical applications
AU - Doll, Tais A.P.F.
AU - Raman, Senthilkumar
AU - Dey, Raja
AU - Burkhard, Peter
PY - 2013/3/6
Y1 - 2013/3/6
N2 - Nanoscale assemblies are a unique class of materials, which can be synthesized from inorganic, polymeric or biological building blocks. The multitude of applications of this class of materials ranges from solar and electrical to uses in food, cosmetics and medicine. In this review, we initially highlight characteristic features of polymeric nanoscale assemblies as well as those built from biological units (lipids, nucleic acids and proteins). We give special consideration to protein nanoassemblies found in nature such as ferritin protein cages, bacterial microcompartments and vaults found in eukaryotic cells and designed protein nanoassemblies, such as peptide nanofibres and peptide nanotubes. Next, we focus on biomedical applications of these nanoscale assemblies, such as cell targeting, drug delivery, bioimaging and vaccine development. In the vaccine development section, we report in more detail the use of virus-like particles and self-assembling polypeptide nanoparticles as new vaccine delivery platforms.
AB - Nanoscale assemblies are a unique class of materials, which can be synthesized from inorganic, polymeric or biological building blocks. The multitude of applications of this class of materials ranges from solar and electrical to uses in food, cosmetics and medicine. In this review, we initially highlight characteristic features of polymeric nanoscale assemblies as well as those built from biological units (lipids, nucleic acids and proteins). We give special consideration to protein nanoassemblies found in nature such as ferritin protein cages, bacterial microcompartments and vaults found in eukaryotic cells and designed protein nanoassemblies, such as peptide nanofibres and peptide nanotubes. Next, we focus on biomedical applications of these nanoscale assemblies, such as cell targeting, drug delivery, bioimaging and vaccine development. In the vaccine development section, we report in more detail the use of virus-like particles and self-assembling polypeptide nanoparticles as new vaccine delivery platforms.
KW - Drug delivery
KW - Nanoparticle
KW - Nanoscale assemblies
KW - Peptide nanoparticles
KW - Vaccines
KW - Virus-like particles
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U2 - 10.1098/rsif.2012.0740
DO - 10.1098/rsif.2012.0740
M3 - Review article
C2 - 23303217
AN - SCOPUS:84879137858
SN - 1742-5689
VL - 10
JO - Journal of the Royal Society Interface
JF - Journal of the Royal Society Interface
IS - 80
ER -