Nanomagnetic competition assay for low-abundance protein biomarker quantification in unprocessed human sera

Yuanpeng Li; Balasubramanian Srinivasan; Ying Jing; Xiaofeng Yao; Marie A. Hugger; Jian Ping Wang; Chengguo Xing

doi:10.1021/ja910406a

Nanomagnetic competition assay for low-abundance protein biomarker quantification in unprocessed human sera

Yuanpeng Li, Balasubramanian Srinivasan, Ying Jing, Xiaofeng Yao, Marie A. Hugger, Jian Ping Wang, Chengguo Xing

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

A novel giant magnetoresistive sensor and uniform high-magnetic-moment FeCo nanoparticles (12.8 nm)-based detecting platform with minimized detecting distance was developed for rapid biomolecule quantification from body fluids. Such a system demonstrates specific, accurate, and quick detection and quantification of interleukin-6, a low-abundance protein and a potential cancer biomarker, directly in 4 L of unprocessed human sera. This platform is expected to facilitate the identification and validation of disease biomarkers. It may eventually lead to a low-cost personal medical device for chronic disease early detection, diagnosis, and prognosis.

Original language	English (US)
Pages (from-to)	4388-4392
Number of pages	5
Journal	Journal of the American Chemical Society
Volume	132
Issue number	12
DOIs	https://doi.org/10.1021/ja910406a
State	Published - Mar 31 2010

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abstract = "A novel giant magnetoresistive sensor and uniform high-magnetic-moment FeCo nanoparticles (12.8 nm)-based detecting platform with minimized detecting distance was developed for rapid biomolecule quantification from body fluids. Such a system demonstrates specific, accurate, and quick detection and quantification of interleukin-6, a low-abundance protein and a potential cancer biomarker, directly in 4 L of unprocessed human sera. This platform is expected to facilitate the identification and validation of disease biomarkers. It may eventually lead to a low-cost personal medical device for chronic disease early detection, diagnosis, and prognosis.",

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AU - Yao, Xiaofeng

AU - Hugger, Marie A.

AU - Wang, Jian Ping

AU - Xing, Chengguo

PY - 2010/3/31

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AB - A novel giant magnetoresistive sensor and uniform high-magnetic-moment FeCo nanoparticles (12.8 nm)-based detecting platform with minimized detecting distance was developed for rapid biomolecule quantification from body fluids. Such a system demonstrates specific, accurate, and quick detection and quantification of interleukin-6, a low-abundance protein and a potential cancer biomarker, directly in 4 L of unprocessed human sera. This platform is expected to facilitate the identification and validation of disease biomarkers. It may eventually lead to a low-cost personal medical device for chronic disease early detection, diagnosis, and prognosis.

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Nanomagnetic competition assay for low-abundance protein biomarker quantification in unprocessed human sera

Abstract

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