Nanomagnetic competition assay for low-abundance protein biomarker quantification in unprocessed human sera

Yuanpeng Li, Balasubramanian Srinivasan, Ying Jing, Xiaofeng Yao, Marie A. Hugger, Jianping Wang, Chengguo Xing

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

A novel giant magnetoresistive sensor and uniform high-magnetic-moment FeCo nanoparticles (12.8 nm)-based detecting platform with minimized detecting distance was developed for rapid biomolecule quantification from body fluids. Such a system demonstrates specific, accurate, and quick detection and quantification of interleukin-6, a low-abundance protein and a potential cancer biomarker, directly in 4 L of unprocessed human sera. This platform is expected to facilitate the identification and validation of disease biomarkers. It may eventually lead to a low-cost personal medical device for chronic disease early detection, diagnosis, and prognosis.

Original languageEnglish (US)
Pages (from-to)4388-4392
Number of pages5
JournalJournal of the American Chemical Society
Volume132
Issue number12
DOIs
StatePublished - Mar 31 2010

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