Nanofunnels for probing the local chain statistics of confined single DNA molecules

Damini Gupta; Jeremy J. Miller; Sara Mahshid; Walter Reisner; Kevin D. Dorfman

Nanofunnels for probing the local chain statistics of confined single DNA molecules

Damini Gupta
, Jeremy J. Miller
, Sara Mahshid
, Walter Reisner
, Kevin D. Dorfman

Chemical Engineering and Materials Science

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Here we review two recent studies that independently report the experimental proof of weak excluded volume effects when DNA is confined to a nanochannel in the extended de Gennes regime [1,2]. Interestingly, similar conclusions are derived using two different approaches. These results are important to the fundamental understanding of confined semiflexible chains like DNA, providing strong experimental confirmation of a key theoretical prediction [3-6].

Original language	English (US)
Title of host publication	MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Publisher	Chemical and Biological Microsystems Society
Pages	1121-1123
Number of pages	3
ISBN (Electronic)	9780979806483
State	Published - 2015
Event	19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of Duration: Oct 25 2015 → Oct 29 2015

Publication series

Name	MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Other

Other	19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
Country/Territory	Korea, Republic of
City	Gyeongju
Period	10/25/15 → 10/29/15

Bibliographical note

Funding Information:
This work was supported by grants from the NIH (R01-HG006851) and NSF (DMR-1206045) to K.D.D, a grant from NSERC (DG 386212-10) to W.R., a grant from FQRNT to W.R. (2015-PR-180418), and a Canadian Health Research Projects (CHRP) award to W.R. with joint contributions from the National Science and Engineering Research Council of Canada (NSERC, 446656-13) and Canadian Institute for Health Research (CIHR, CPG-127762).

Publisher Copyright:
© 15CBMS-0001.

Keywords

Confinement
DNA
Extension
Fluctuation
Nanochannels
Single-Molecule

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Gupta, D., Miller, J. J., Mahshid, S., Reisner, W., & Dorfman, K. D. (2015). Nanofunnels for probing the local chain statistics of confined single DNA molecules. In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1121-1123). (MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.

Nanofunnels for probing the local chain statistics of confined single DNA molecules. / Gupta, Damini; Miller, Jeremy J.; Mahshid, Sara et al.
MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2015. p. 1121-1123 (MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Gupta, D, Miller, JJ, Mahshid, S, Reisner, W & Dorfman, KD 2015, Nanofunnels for probing the local chain statistics of confined single DNA molecules. in MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society, pp. 1121-1123, 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015, Gyeongju, Korea, Republic of, 10/25/15.

Gupta D, Miller JJ, Mahshid S, Reisner W, Dorfman KD. Nanofunnels for probing the local chain statistics of confined single DNA molecules. In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society. 2015. p. 1121-1123. (MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

Gupta, Damini ; Miller, Jeremy J. ; Mahshid, Sara et al. / Nanofunnels for probing the local chain statistics of confined single DNA molecules. MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2015. pp. 1121-1123 (MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

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title = "Nanofunnels for probing the local chain statistics of confined single DNA molecules",

abstract = "Here we review two recent studies that independently report the experimental proof of weak excluded volume effects when DNA is confined to a nanochannel in the extended de Gennes regime [1,2]. Interestingly, similar conclusions are derived using two different approaches. These results are important to the fundamental understanding of confined semiflexible chains like DNA, providing strong experimental confirmation of a key theoretical prediction [3-6].",

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note = "Funding Information: This work was supported by grants from the NIH (R01-HG006851) and NSF (DMR-1206045) to K.D.D, a grant from NSERC (DG 386212-10) to W.R., a grant from FQRNT to W.R. (2015-PR-180418), and a Canadian Health Research Projects (CHRP) award to W.R. with joint contributions from the National Science and Engineering Research Council of Canada (NSERC, 446656-13) and Canadian Institute for Health Research (CIHR, CPG-127762). Publisher Copyright: {\textcopyright} 15CBMS-0001.; 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 ; Conference date: 25-10-2015 Through 29-10-2015",

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AU - Miller, Jeremy J.

AU - Mahshid, Sara

AU - Reisner, Walter

AU - Dorfman, Kevin D.

N1 - Funding Information: This work was supported by grants from the NIH (R01-HG006851) and NSF (DMR-1206045) to K.D.D, a grant from NSERC (DG 386212-10) to W.R., a grant from FQRNT to W.R. (2015-PR-180418), and a Canadian Health Research Projects (CHRP) award to W.R. with joint contributions from the National Science and Engineering Research Council of Canada (NSERC, 446656-13) and Canadian Institute for Health Research (CIHR, CPG-127762). Publisher Copyright: © 15CBMS-0001.

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N2 - Here we review two recent studies that independently report the experimental proof of weak excluded volume effects when DNA is confined to a nanochannel in the extended de Gennes regime [1,2]. Interestingly, similar conclusions are derived using two different approaches. These results are important to the fundamental understanding of confined semiflexible chains like DNA, providing strong experimental confirmation of a key theoretical prediction [3-6].

AB - Here we review two recent studies that independently report the experimental proof of weak excluded volume effects when DNA is confined to a nanochannel in the extended de Gennes regime [1,2]. Interestingly, similar conclusions are derived using two different approaches. These results are important to the fundamental understanding of confined semiflexible chains like DNA, providing strong experimental confirmation of a key theoretical prediction [3-6].

KW - Confinement

KW - DNA

KW - Extension

KW - Fluctuation

KW - Nanochannels

KW - Single-Molecule

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M3 - Conference contribution

AN - SCOPUS:84983257885

T3 - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

SP - 1121

EP - 1123

BT - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

PB - Chemical and Biological Microsystems Society

T2 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015

Y2 - 25 October 2015 through 29 October 2015

ER -

Nanofunnels for probing the local chain statistics of confined single DNA molecules

Abstract

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Bibliographical note

Keywords

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