Nanofunnels for probing the local chain statistics of confined single DNA molecules

Damini Gupta, Jeremy J. Miller, Sara Mahshid, Walter Reisner, Kevin D. Dorfman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Here we review two recent studies that independently report the experimental proof of weak excluded volume effects when DNA is confined to a nanochannel in the extended de Gennes regime [1,2]. Interestingly, similar conclusions are derived using two different approaches. These results are important to the fundamental understanding of confined semiflexible chains like DNA, providing strong experimental confirmation of a key theoretical prediction [3-6].

Original languageEnglish (US)
Title of host publicationMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1121-1123
Number of pages3
ISBN (Electronic)9780979806483
StatePublished - 2015
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of
Duration: Oct 25 2015Oct 29 2015

Publication series

NameMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Other

Other19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
CountryKorea, Republic of
CityGyeongju
Period10/25/1510/29/15

Bibliographical note

Funding Information:
This work was supported by grants from the NIH (R01-HG006851) and NSF (DMR-1206045) to K.D.D, a grant from NSERC (DG 386212-10) to W.R., a grant from FQRNT to W.R. (2015-PR-180418), and a Canadian Health Research Projects (CHRP) award to W.R. with joint contributions from the National Science and Engineering Research Council of Canada (NSERC, 446656-13) and Canadian Institute for Health Research (CIHR, CPG-127762).

Keywords

  • Confinement
  • DNA
  • Extension
  • Fluctuation
  • Nanochannels
  • Single-Molecule

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