Abstract
Here we review two recent studies that independently report the experimental proof of weak excluded volume effects when DNA is confined to a nanochannel in the extended de Gennes regime [1,2]. Interestingly, similar conclusions are derived using two different approaches. These results are important to the fundamental understanding of confined semiflexible chains like DNA, providing strong experimental confirmation of a key theoretical prediction [3-6].
| Original language | English (US) |
|---|---|
| Title of host publication | MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 1121-1123 |
| Number of pages | 3 |
| ISBN (Electronic) | 9780979806483 |
| State | Published - 2015 |
| Event | 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of Duration: Oct 25 2015 → Oct 29 2015 |
Publication series
| Name | MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
|---|
Other
| Other | 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 |
|---|---|
| Country/Territory | Korea, Republic of |
| City | Gyeongju |
| Period | 10/25/15 → 10/29/15 |
Bibliographical note
Funding Information:This work was supported by grants from the NIH (R01-HG006851) and NSF (DMR-1206045) to K.D.D, a grant from NSERC (DG 386212-10) to W.R., a grant from FQRNT to W.R. (2015-PR-180418), and a Canadian Health Research Projects (CHRP) award to W.R. with joint contributions from the National Science and Engineering Research Council of Canada (NSERC, 446656-13) and Canadian Institute for Health Research (CIHR, CPG-127762).
Publisher Copyright:
© 15CBMS-0001.
Keywords
- Confinement
- DNA
- Extension
- Fluctuation
- Nanochannels
- Single-Molecule