Here we review two recent studies that independently report the experimental proof of weak excluded volume effects when DNA is confined to a nanochannel in the extended de Gennes regime [1,2]. Interestingly, similar conclusions are derived using two different approaches. These results are important to the fundamental understanding of confined semiflexible chains like DNA, providing strong experimental confirmation of a key theoretical prediction [3-6].
|Original language||English (US)|
|Title of host publication||MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences|
|Publisher||Chemical and Biological Microsystems Society|
|Number of pages||3|
|State||Published - 2015|
|Event||19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of|
Duration: Oct 25 2015 → Oct 29 2015
|Name||MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences|
|Other||19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015|
|Country||Korea, Republic of|
|Period||10/25/15 → 10/29/15|
Bibliographical noteFunding Information:
This work was supported by grants from the NIH (R01-HG006851) and NSF (DMR-1206045) to K.D.D, a grant from NSERC (DG 386212-10) to W.R., a grant from FQRNT to W.R. (2015-PR-180418), and a Canadian Health Research Projects (CHRP) award to W.R. with joint contributions from the National Science and Engineering Research Council of Canada (NSERC, 446656-13) and Canadian Institute for Health Research (CIHR, CPG-127762).