CK2, a pleiotropic Ser/Thr kinase, is an important target for cancer therapy. We tested our novel tenfibgen-based nanocapsule for delivery of the inhibitor 2-dimethylamino-4,5,6,7-tetrabromo-1. H-benzimidazole (DMAT) and an siRNA directed against both CK2α and α' catalytic subunits to prostate cancer cells. We present data on the TBG nanocapsule itself and on CK2 inhibition or downregulation in treated cells, including effects on Nuclear Factor-kappa B (NF-κB) p65. By direct comparison of two CK2-directed cargos, our data provide proof that the TBG encapsulation design for delivery of drugs specifically to cancer cells has strong potential for small molecule- and nucleic acid-based cancer therapy.
|Original language||English (US)|
|Number of pages||11|
|State||Published - Feb 1 2012|
Bibliographical noteFunding Information:
Grant Sponsors: Department of Veterans Affairs Medical Research Merit Review Funds (K.A.); National Cancer Institute grant numbers UO1-CA15062 (K.A.) and RO1-CA150182 (K.A.); Ministry of Science and Higher Education of Poland, grant N N209 371439 (Z.K.); AIRC, Associazione Italiana per la Ricerca sul Cancro (L.A.P); National Institute of Health grant number R01-DK067436 (B.T.K).
- Prostate cancer