Optical tweezers were developed in 1970 by Arthur Ashkin as a tool for the manipulation of micron-sized particles. Ashkin's original design was then adapted for a variety of purposes, such as trapping and manipulation of biological materials and the laser cooling of atoms.[2,3] More recent development has led to nano-optical tweezers, for trapping particles on the scale of only a few nanometers, and holographic tweezers, which allow for dynamic control of multiple traps in real-time. These alternatives to conventional optical tweezers have made it possible to trap single molecules and to perform a variety of studies on them. Presented here is a review of recent developments in nano-optical tweezers and their current and future applications.
Bibliographical noteFunding Information:
The authors acknowledge support provided by the Minnesota Environment and Natural Resources Trust Fund as recommended by the Legislative‐Citizen Commission on Minnesota Resources (LCCMR) and the Sanford P. Bordeau Chair in Electrical Engineering at the University of Minnesota. N.C.L. acknowledges support from the National Science Foundation (1552642).
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- Raman spectroscopy
- scanning probe microscopy
- single-molecule studies
PubMed: MeSH publication types
- Journal Article
- Research Support, Non-U.S. Gov't