Nano-lamp arrays for multiplex microfluidic SPR biosensing

Antoine Lesuffleur, Hyungsoon Im, Nathan C. Lindquist, Kwan Seop Lim, Sang Hyun Oh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Surface Plasmon Resonance imaging (SPRi) is a powerful technique for highthroughput, real-time, label-free characterization of molecular interactions. The recent discovery of extraordinary optical transmission through periodic nanohole arrays in a metallic film [1] led to many novel applications, including SPR biosensing. Here, we demonstrate integrating several nanohole arrays for multiplex SPR detection using a laser source and a CCD camera for imaging transmission through each array in a real-time manner. Binding kinetics of self-assembled monolayer (SAM) adsorption onto the gold surface and specific interactions between biotin and streptavidin were imaged in real-time using the nanoscale LAserilluminated Metal Pores (nano-LAMP) system.

Original languageEnglish (US)
Title of host publication12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference
PublisherChemical and Biological Microsystems Society
Pages955-957
Number of pages3
StatePublished - Jan 1 2008
Event12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States
Duration: Oct 12 2008Oct 16 2008

Other

Other12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008
CountryUnited States
CitySan Diego, CA
Period10/12/0810/16/08

Keywords

  • Label-free biosensing
  • Nanohole array
  • Surface plasmon resonance

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