Naltrexone and relapse prevention treatment for cocaine-dependent patients

J. M. Schmitz, A. L. Stotts, H. M. Rhoades, J. Grabowski

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

A double-blind, placebo-controlled clinical trial examining the joint action of naltrexone (NTX) in combination with relapse prevention (RP) therapy for the treatment of cocaine dependence was conducted. Eighty-five participants who achieved initial abstinence during the intake evaluation and detoxification phase of the study were randomized into 1 of 4 combined NTX (0 vs. 50 mg) by therapy (RP vs. Drug Counseling) experimental conditions for the 12-week outpatient treatment phase of the study. A random effects regression model to test for group differences on percentage of cocaine-positive urines indicated a significant time by medication by therapy interaction, suggesting less cocaine use over time among subjects receiving RP-50mg than those in the other conditions. No differences were found for retention or time until first cocaine-positive urine. Naltrexone was well tolerated by participants, with acceptable rates of medication compliance observed. Treatment integrity measures confirmed successful manipulation of the psychotherapy. These results are consistent with the notion that substance use in dependent patients can be reduced with a combination of coping skills training and pharmacologic treatments.

Original languageEnglish (US)
Pages (from-to)167-180
Number of pages14
JournalAddictive Behaviors
Volume26
Issue number2
DOIs
StatePublished - Mar 4 2001

Fingerprint

Naltrexone
Secondary Prevention
Cocaine
Detoxification
Therapeutics
Urine
Cocaine-Related Disorders
Medication Adherence
Psychological Adaptation
Controlled Clinical Trials
Psychotherapy
Counseling
Pharmaceutical Preparations
Outpatients
Placebos

Keywords

  • Cocaine
  • Naltrexone
  • Pharmacotherapy
  • Psychotherapy
  • Relapse prevention therapy

Cite this

Naltrexone and relapse prevention treatment for cocaine-dependent patients. / Schmitz, J. M.; Stotts, A. L.; Rhoades, H. M.; Grabowski, J.

In: Addictive Behaviors, Vol. 26, No. 2, 04.03.2001, p. 167-180.

Research output: Contribution to journalArticle

Schmitz, J. M. ; Stotts, A. L. ; Rhoades, H. M. ; Grabowski, J. / Naltrexone and relapse prevention treatment for cocaine-dependent patients. In: Addictive Behaviors. 2001 ; Vol. 26, No. 2. pp. 167-180.
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