Naloxone but not CCK-8 may attenuate binge-eating behavior in patients with the bulimia syndrome

James E. Mitchell; Dawn E. Laine; John E. Morley; Allen S Levine

doi:10.1016/0006-3223(86)90331-8

Naloxone but not CCK-8 may attenuate binge-eating behavior in patients with the bulimia syndrome

James E. Mitchell, Dawn E. Laine, John E. Morley, Allen S Levine

Food Science and Nutrition

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Abstract

We undertook a study to see if putative anorectic agents could attenuate binge eating episodes in bulimic patients. Bolus intravenous administration, followed by continuous intravenous infusion of naloxone, resulted in a significant decrease in the amount of food consumed during binge-eating episodes, whereas bolus followed by continuous intravenous infusion of CCK-8 failed to significantly suppress binge eating behavior. These results suggest that the endogenous opioid system is involved in the maintenance of binge eating behavior in patients with bulimia.

Original language	English (US)
Pages (from-to)	1399-1406
Number of pages	8
Journal	Biological psychiatry
Volume	21
Issue number	14
DOIs	https://doi.org/10.1016/0006-3223(86)90331-8
State	Published - Dec 1986

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title = "Naloxone but not CCK-8 may attenuate binge-eating behavior in patients with the bulimia syndrome",

abstract = "We undertook a study to see if putative anorectic agents could attenuate binge eating episodes in bulimic patients. Bolus intravenous administration, followed by continuous intravenous infusion of naloxone, resulted in a significant decrease in the amount of food consumed during binge-eating episodes, whereas bolus followed by continuous intravenous infusion of CCK-8 failed to significantly suppress binge eating behavior. These results suggest that the endogenous opioid system is involved in the maintenance of binge eating behavior in patients with bulimia.",

author = "Mitchell, {James E.} and Laine, {Dawn E.} and Morley, {John E.} and Levine, {Allen S}",

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AU - Levine, Allen S

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AB - We undertook a study to see if putative anorectic agents could attenuate binge eating episodes in bulimic patients. Bolus intravenous administration, followed by continuous intravenous infusion of naloxone, resulted in a significant decrease in the amount of food consumed during binge-eating episodes, whereas bolus followed by continuous intravenous infusion of CCK-8 failed to significantly suppress binge eating behavior. These results suggest that the endogenous opioid system is involved in the maintenance of binge eating behavior in patients with bulimia.

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Naloxone but not CCK-8 may attenuate binge-eating behavior in patients with the bulimia syndrome

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