Naloxone but not CCK-8 may attenuate binge-eating behavior in patients with the bulimia syndrome

James E. Mitchell, Dawn E. Laine, John E. Morley, Allen S Levine

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

We undertook a study to see if putative anorectic agents could attenuate binge eating episodes in bulimic patients. Bolus intravenous administration, followed by continuous intravenous infusion of naloxone, resulted in a significant decrease in the amount of food consumed during binge-eating episodes, whereas bolus followed by continuous intravenous infusion of CCK-8 failed to significantly suppress binge eating behavior. These results suggest that the endogenous opioid system is involved in the maintenance of binge eating behavior in patients with bulimia.

Original languageEnglish (US)
Pages (from-to)1399-1406
Number of pages8
JournalBiological Psychiatry
Volume21
Issue number14
DOIs
StatePublished - Dec 1986

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