Naloxone administration following operant training of sucrose/water discrimination in the rat

E. O'Hare, J. Cleary, P. J. Bartz, D. T. Weldon, Charles J Billington, Allen S Levine

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32 Scopus citations

Abstract

The suppression of food intake observed following naloxone administration has often been ascribed to palatability or taste. Unfortunately, many confounds become apparent when attempts are made to isolate such factors in the investigation of ingestive behaviors. In the present study, rats (two groups) were trained to discriminate either a 10% or 5% sucrose solution from water (0.1 ml). These mildly food deprived subjects (95% of free-feeding weight) were trained to press the appropriate lever in a two-lever operant chamber following sampling of sucrose or water; successful responding was reinforced by delivery of a 45 mg grain food pellet. Following random exposure to reduced sucrose concentrations tested under extinction, a sucrose concentration gradient (1.0, 0.5, 0.1, 0.05, 0.01 and 0.005% sucrose solution) was established for both training groups under IP saline administration. Data collected under IP saline were then compared to those collected following random IP naloxone administration (3.0, 1.0, 0.3 and 0.1 mg/kg). No significant differences were observed between the sucrose concentration gradients obtained under saline and those obtained under naloxone, suggesting that the anorectic effect of naloxone is not primarily determined by discrimination of sweet taste.

Original languageEnglish (US)
Pages (from-to)289-294
Number of pages6
JournalPsychopharmacology
Volume129
Issue number3
DOIs
StatePublished - Mar 3 1997

Keywords

  • Discrimination
  • Naloxone
  • Opioids
  • Sucrose
  • Taste

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