Naked-eye visualization of nucleic acid amplicons using hierarchical nanoassembly

Vinni Thekkudan Novi; Abdennour Abbas

doi:10.1039/d3ay01050c

Naked-eye visualization of nucleic acid amplicons using hierarchical nanoassembly

Vinni Thekkudan Novi, Abdennour Abbas

Bioproducts and Biosystems Engineering

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

This study reports the development of a rapid visualization method for DNA amplicons. Oligonucleotide-coated gold nanoparticles hierarchically assemble on DNA networks to form globular nanostructures, which precipitate into a distinct visible red pellet. This aims to overcome challenges associated with nanoparticle aggregation and dye-based colorimetric detection in LAMP assays.

Original language	English (US)
Pages (from-to)	4640-4644
Number of pages	5
Journal	Analytical Methods
Volume	15
Issue number	36
DOIs	https://doi.org/10.1039/d3ay01050c
State	Published - Aug 3 2023

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© 2023 The Royal Society of Chemistry.

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

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10.1039/d3ay01050c

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abstract = "This study reports the development of a rapid visualization method for DNA amplicons. Oligonucleotide-coated gold nanoparticles hierarchically assemble on DNA networks to form globular nanostructures, which precipitate into a distinct visible red pellet. This aims to overcome challenges associated with nanoparticle aggregation and dye-based colorimetric detection in LAMP assays.",

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AB - This study reports the development of a rapid visualization method for DNA amplicons. Oligonucleotide-coated gold nanoparticles hierarchically assemble on DNA networks to form globular nanostructures, which precipitate into a distinct visible red pellet. This aims to overcome challenges associated with nanoparticle aggregation and dye-based colorimetric detection in LAMP assays.

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Naked-eye visualization of nucleic acid amplicons using hierarchical nanoassembly

Abstract

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