Naftifine gel in the treatment of tinea pedis: Two double-blind, multicenter studies

F. K. Bagatell, B. J. Bart, G. W. Cole, L. A. Drake, C. N. Ellis, S. Fischer, A. H. Greenspan, A. C. Huntley, C. Jacobson, J. L. Jorizzo, R. Kim, N. J. Lowe, B. H. Miller, T. P. Nigra, H. L. Roth, J. L. Shupack, J. Sefton, S. H. Dromgoole, D. A. Lew-Kaya

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17 Scopus citations


Three hundred and sixteen patients with a diagnosis of tinea pedis were evaluated in two multicenter, double-blind randomized studies. One hundred and fifty-nine patients applied naftifine gel 1 percent and 157 applied gel vehicle to affected areas twice daily for four weeks. At the end of treatment, the naftifine-treated groups had higher mycologic cure rates (66 percent and 63 percent) than the respective vehicle-treated groups (34 percent and 27 percent, p is less than 0.01 and p is less than 0.001). The rate of global improvement in patients' conditions and the reduction in the incidence and severity of most signs and symptoms was greater for naftifine-treated patients in both studies. The results of these studies indicate that twice-daily use of naftifine gel 1 percent is safe and significantly more effective than vehicle in the treatment of tinea pedis.

Original languageEnglish (US)
Pages (from-to)85-88
Number of pages4
Issue number1
StatePublished - 1991
Externally publishedYes


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