Naïve and memory CD4+ T cell survival controlled by clonal abundance

Jason Hataye, James J. Moon, Alexander Khoruts, Cavan Reilly, Marc K. Jenkins

Research output: Contribution to journalArticlepeer-review

267 Scopus citations

Abstract

Immunity to a plethora of microbes depends on a diverse repertoire of naïve lymphocytes and the production of long-lived memory cells. We present evidence here that low clonal abundance in a polyclonal repertoire favors the survival and activation of naïve CD4+ T cells as well as the survival of their memory cell progeny. The inverse relation between clonal frequency and survival suggests that intraclonal competition could help maintain an optimally diverse repertoire of T cells and an optimal environment for the generation of long-lived memory cells.

Original languageEnglish (US)
Pages (from-to)114-116
Number of pages3
JournalScience
Volume312
Issue number5770
DOIs
StatePublished - Apr 7 2006

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