N-terminal-proB-type natriuretic peptide predicts cardiovascular disease events in HIV-infected patients

Daniel A. Duprez, Jacqueline Neuhaus, Russell Tracy, Lewis H. Kuller, Steven G. Deeks, Chloe Orkin, Albrecht Stoehr, Ian J. Woolley, James D. Neaton

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Background: Cardiovascular disease (CVD) is increasing in HIV-infected patients. N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a significant predictor of CVD in the general population. We aimed to quantify the risk of CVD events associated with NT-proBNP at baseline in the Strategies for Management of Anti-Retroviral Therapy study. Methods: In a nested case-control study, NT-proBNP was measured at baseline in 186 patients who experienced a CVD event over an average of 2.8 years of follow-up and in 329 matched controls. Odds ratios (ORs) associated with baseline levels of NT-proBNP for CVD were estimated using conditional logistic regression. Results: At baseline median NT-proBNP [interquartile range (IQR)] was 48.1 (18.5, 112.9) pg/ml in patients who developed a CVD event and 25.7 (12.4, 50.2) pg/ml in controls. The unadjusted OR for the highest versus the lowest quartile was 3.7 [95% confidence interval (CI) 2.1-6.5, P < 0.0001]. After adjustment for baseline covariates and CVD risk factors, OR was 2.8 (95% CI 1.4-5.6, P = 0.003); with additional adjustment for IL-6, high-sensitivity C-reactive protein and D-dimer, OR was 2.3 (95% CI 1.1-4.9, P = 0.02). Conclusions: Higher levels of NT-proBNP are associated with increased risk of CVD in HIV patients after considering established CVD risk factors and markers for inflammation and thrombosis.

Original languageEnglish (US)
Pages (from-to)651-657
Number of pages7
Issue number5
StatePublished - Mar 13 2011


  • AIDS
  • HIV
  • NT-proBNP
  • antiretroviral therapy
  • cardiovascular disease events


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