N-terminal pro B-type natriuretic peptide predicts mortality in patients with left ventricular hypertrophy

Santiago Garcia, Muhammad S. Akbar, Syed S. Ali, Forum Kamdar, Michael Y. Tsai, Daniel A. Duprez

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Background: Left ventricular hypertrophy adversely affects outcomes in patients with hypertension. Whether N-terminal pro B-type natriuretic peptide (NT-proBNP) adds incremental prognostic information in patients with hypertension and left ventricular hypertrophy (LVH) is not well established. We aimed to study the prognostic value of NT-proBNP in hypertensive patients with LVH. Methods: Echocardiography was performed in 232 patients (mean age 61 ± 15, 102 males, 130 females) for the diagnosis of left ventricular hypertrophy. Left ventricular mass was measured according to The American Society of Echocardiography guidelines. A blood sample was taken for NT-proBNP determination. NT-proBNP levels were analyzed in quartiles after log transformation. Long term survival was established by review of electronic medical records. Results: Arterial hypertension was present in 130 patients (56%) and left ventricular hypertrophy was present in 105 patients (45%). In patients with left ventricular hypertrophy, NT-proBNP levels predicted long term survival (Chi-square = 10, p = 0.01). After adjusting by age, presence of coronary artery disease, ejection fraction, diabetes status, and hypertension; patients in highest NT pro-BNP quartile were twice as likely to die when compared to patients in the lowest NT-ptoBNP quartile (OR = 2.2, 95% CI = 1.0-4.6, p = 0.03). Conclusion: NT-proBNP is an independent predictor of survival in patients with hypertension and increased left ventricular mass.

Original languageEnglish (US)
Pages (from-to)349-352
Number of pages4
JournalInternational Journal of Cardiology
Volume143
Issue number3
DOIs
StatePublished - Sep 3 2010

Keywords

  • Hypertension
  • Left ventricular hypertrophy
  • Natriuretic peptides

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