TY - JOUR
T1 - N-terminal pro B-type natriuretic peptide predicts mortality in patients with left ventricular hypertrophy
AU - Garcia, Santiago
AU - Akbar, Muhammad S.
AU - Ali, Syed S.
AU - Kamdar, Forum
AU - Tsai, Michael Y.
AU - Duprez, Daniel A.
PY - 2010/9/3
Y1 - 2010/9/3
N2 - Background: Left ventricular hypertrophy adversely affects outcomes in patients with hypertension. Whether N-terminal pro B-type natriuretic peptide (NT-proBNP) adds incremental prognostic information in patients with hypertension and left ventricular hypertrophy (LVH) is not well established. We aimed to study the prognostic value of NT-proBNP in hypertensive patients with LVH. Methods: Echocardiography was performed in 232 patients (mean age 61 ± 15, 102 males, 130 females) for the diagnosis of left ventricular hypertrophy. Left ventricular mass was measured according to The American Society of Echocardiography guidelines. A blood sample was taken for NT-proBNP determination. NT-proBNP levels were analyzed in quartiles after log transformation. Long term survival was established by review of electronic medical records. Results: Arterial hypertension was present in 130 patients (56%) and left ventricular hypertrophy was present in 105 patients (45%). In patients with left ventricular hypertrophy, NT-proBNP levels predicted long term survival (Chi-square = 10, p = 0.01). After adjusting by age, presence of coronary artery disease, ejection fraction, diabetes status, and hypertension; patients in highest NT pro-BNP quartile were twice as likely to die when compared to patients in the lowest NT-ptoBNP quartile (OR = 2.2, 95% CI = 1.0-4.6, p = 0.03). Conclusion: NT-proBNP is an independent predictor of survival in patients with hypertension and increased left ventricular mass.
AB - Background: Left ventricular hypertrophy adversely affects outcomes in patients with hypertension. Whether N-terminal pro B-type natriuretic peptide (NT-proBNP) adds incremental prognostic information in patients with hypertension and left ventricular hypertrophy (LVH) is not well established. We aimed to study the prognostic value of NT-proBNP in hypertensive patients with LVH. Methods: Echocardiography was performed in 232 patients (mean age 61 ± 15, 102 males, 130 females) for the diagnosis of left ventricular hypertrophy. Left ventricular mass was measured according to The American Society of Echocardiography guidelines. A blood sample was taken for NT-proBNP determination. NT-proBNP levels were analyzed in quartiles after log transformation. Long term survival was established by review of electronic medical records. Results: Arterial hypertension was present in 130 patients (56%) and left ventricular hypertrophy was present in 105 patients (45%). In patients with left ventricular hypertrophy, NT-proBNP levels predicted long term survival (Chi-square = 10, p = 0.01). After adjusting by age, presence of coronary artery disease, ejection fraction, diabetes status, and hypertension; patients in highest NT pro-BNP quartile were twice as likely to die when compared to patients in the lowest NT-ptoBNP quartile (OR = 2.2, 95% CI = 1.0-4.6, p = 0.03). Conclusion: NT-proBNP is an independent predictor of survival in patients with hypertension and increased left ventricular mass.
KW - Hypertension
KW - Left ventricular hypertrophy
KW - Natriuretic peptides
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U2 - 10.1016/j.ijcard.2009.03.070
DO - 10.1016/j.ijcard.2009.03.070
M3 - Article
C2 - 19356808
AN - SCOPUS:77956612518
SN - 0167-5273
VL - 143
SP - 349
EP - 352
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 3
ER -
