N′-nitrosonornicotine in tobacco

Dietrich Hoffmann, Stephen S. Hecht, Raphael M. Ornaf, Ernst L. Wynder

Research output: Contribution to journalArticle

97 Scopus citations


N′-Nitrosonornicotine, a potential carcinogen, has been positively identified in unburned tobacco. The amount in commercial U.S. tobacco products is between 1.9 to 88.6 parts per million, one of the highest values of an environmental nitrosamine yet reported. The amount in food and drink rarely exceeds 0.1 part per million. This compound is the first example of a potential organic carcinogen isolated from tobacco.

Original languageEnglish (US)
Pages (from-to)265-267
Number of pages3
Issue number4160
StatePublished - Jan 1 1974
Externally publishedYes

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    Hoffmann, D., Hecht, S. S., Ornaf, R. M., & Wynder, E. L. (1974). N′-nitrosonornicotine in tobacco. Science, 186(4160), 265-267. https://doi.org/10.1126/science.186.4160.265