N-nitroso-N-methyldodecylamine and N-nitroso-N-methyltetradecylamine in hair-care products

S. S. Hecht, J. B. Morrison, J. A. Wenninger

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

N-Nitroso-N-methyldodecylamine and N-nitroso-N-methyltetradecylamine, which cause urinary bladder tumours in experimental animals, were detected in several hair-care products formulated with N,N-dimethyldodecylamine oxide. Quantitative determinations were made using a gas-liquid chromatograph interfaced with a thermal energy analyser and using [1-14C]N-nitroso-N-methyldodecylamine as an internal standard. The presence of the two nitrosamines was confirmed by high-pressure liquid chromatography with a thermal energy analyser as detector, by photolysis of samples and by combined gas chromatography-mass spectrometry. To test the reproducibility of the method, a single shampoo was selected for replicate analysis and was found to contain 90 ± 8 ppb N-nitroso-N-methyldodecylamine and 37 ± 11 ppb N-nitroso-N-methyltetradecylamine. Levels of N-nitroso-N-methyldodecylamine in other hair-care products ranged from 11 to 873 ppb and those of N-nitroso-N-methyltetradecylamine from 8 to 254 ppb.

Original languageEnglish (US)
Pages (from-to)165-169
Number of pages5
JournalFood and Chemical Toxicology
Volume20
Issue number2
DOIs
StatePublished - Apr 1982

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hairs
heat
nitrosamines
photolysis
energy
Thermal energy
bladder
reproducibility
detectors
oxides
laboratory animals
high performance liquid chromatography
Hot Temperature
gases
High pressure liquid chromatography
Nitrosamines
liquids
Photolysis
Urinary Bladder Neoplasms
Gas chromatography

Cite this

N-nitroso-N-methyldodecylamine and N-nitroso-N-methyltetradecylamine in hair-care products. / Hecht, S. S.; Morrison, J. B.; Wenninger, J. A.

In: Food and Chemical Toxicology, Vol. 20, No. 2, 04.1982, p. 165-169.

Research output: Contribution to journalArticle

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