Abstract
N-Nitroso-2-hydroxymorpholine was synthesized from N-(2-hydroxyethyl)aminoacetaldehyde diethylacetal by nitrosation and hydrolysis. It was detected as a metabolite of N-nitrosodiethanolamine in rat hepatic 9000 g supernatant. It was mutagenic toward Salmonella typhimurium TA 1535, with and without activation. The results suggest that N-nitroso-2-hydroxymorpholine, which is formed by metabolic β-oxidation of N-nitrosodiethanolamine, could be involved in carcinogenesis by N-nitrosodiethanolamine.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1745-1747 |
| Number of pages | 3 |
| Journal | Carcinogenesis |
| Volume | 5 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1984 |
Bibliographical note
Funding Information:spectra were obtained using the 7T spectrometer at The Rockefeller University, purchased in part with funds from The National Science Foundation (PCM-7912083), The Camille and Henry Dreyfus Foundation, and The Fleischmann Foundation. This is paper No. 76 in the series 'A Study of Chemical Carcinogenesis'.
Funding Information:
This study was supported by NCI Grant CA-23901. I thank George Palladino for the gift of N-(2-hydroxyethyl)aminoacetaldehyde diethy! acetal, Steven Carmella for help with capillary GC, John Adams for help with GC-TEA, Shantu Amin for the liver 9000 g supernatant, Ed LaVoie and Albertina Swanson for mutagenicity assays, J.L.Wiebers for mass spectral determinations, and Dorothy Lin for running 90 MHz n.m.r. spectra. 300 MHz n.m.r.
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