N-nitroso-2-hydroxymorpholine, a mutagenic metabolite of n-nitrosodiethanolamine

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Abstract

N-Nitroso-2-hydroxymorpholine was synthesized from N-(2-hydroxyethyl)aminoacetaldehyde diethylacetal by nitrosation and hydrolysis. It was detected as a metabolite of N-nitrosodiethanolamine in rat hepatic 9000 g supernatant. It was mutagenic toward Salmonella typhimurium TA 1535, with and without activation. The results suggest that N-nitroso-2-hydroxymorpholine, which is formed by metabolic β-oxidation of N-nitrosodiethanolamine, could be involved in carcinogenesis by N-nitrosodiethanolamine.

Original languageEnglish (US)
Pages (from-to)1745-1747
Number of pages3
JournalCarcinogenesis
Volume5
Issue number12
DOIs
StatePublished - Dec 1 1984

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