N-(6,7-Dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-alkylsulfonamides as peripherally restricted N-methyl-d-aspartate receptor antagonists for the treatment of pain

Christopher Deur; Arun K. Agrawal; Heidi Baum; John Booth; Susan Bove; Joan Brieland; Amy Bunker; Cleo Connolly; Joseph Cornicelli; Jo Ann Dumin; Barry Finzel; Xinmin Gan; Sheila Guppy; Gregg Kamilar; Kenneth Kilgore; Pil Lee; Cho Ming Loi; Zhen Lou; Mark Morris; Laurence Philippe; Sally Przybranowski; Frank Riley; Brian Samas; Brian Sanchez; Haile Tecle; Ziqiang Wang; Kathryn Welch; Michael Wilson; Karen Yates

doi:10.1016/j.bmcl.2007.05.083

N-(6,7-Dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-alkylsulfonamides as peripherally restricted N-methyl-d-aspartate receptor antagonists for the treatment of pain

Christopher Deur, Arun K. Agrawal, Heidi Baum, John Booth, Susan Bove, Joan Brieland, Amy Bunker, Cleo Connolly, Joseph Cornicelli, Jo Ann Dumin, Barry Finzel, Xinmin Gan, Sheila Guppy, Gregg Kamilar, Kenneth Kilgore, Pil Lee, Cho Ming Loi, Zhen Lou, Mark Morris, Laurence PhilippeSally Przybranowski, Frank Riley, Brian Samas, Brian Sanchez, Haile Tecle, Ziqiang Wang, Kathryn Welch, Michael Wilson, Karen Yates

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

It has been hypothesized that peripherally restricted NMDA receptor antagonists may be effective analgesics for osteoarthritis pain. A class of novel quinoxalinedione atropisomers, first discovered for an NMDA receptor antagonist program for the treatment of stroke, was evaluated and further optimized with the goal of finding peripherally restricted NMDA receptor antagonists.

Original language	English (US)
Pages (from-to)	4599-4603
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	16
DOIs	https://doi.org/10.1016/j.bmcl.2007.05.083
State	Published - Aug 15 2007

Keywords

NMDA antagonist
Osteoarthritis
Pain

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2007.05.083

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Deur, C., Agrawal, A. K., Baum, H., Booth, J., Bove, S., Brieland, J., Bunker, A., Connolly, C., Cornicelli, J., Dumin, J. A., Finzel, B., Gan, X., Guppy, S., Kamilar, G., Kilgore, K., Lee, P., Loi, C. M., Lou, Z., Morris, M., ... Yates, K. (2007). N-(6,7-Dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-alkylsulfonamides as peripherally restricted N-methyl-d-aspartate receptor antagonists for the treatment of pain. Bioorganic and Medicinal Chemistry Letters, 17(16), 4599-4603. https://doi.org/10.1016/j.bmcl.2007.05.083

N-(6,7-Dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-alkylsulfonamides as peripherally restricted N-methyl-d-aspartate receptor antagonists for the treatment of pain. / Deur, Christopher; Agrawal, Arun K.; Baum, Heidi et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 17, No. 16, 15.08.2007, p. 4599-4603.

Research output: Contribution to journal › Article › peer-review

Deur, C, Agrawal, AK, Baum, H, Booth, J, Bove, S, Brieland, J, Bunker, A, Connolly, C, Cornicelli, J, Dumin, JA, Finzel, B, Gan, X, Guppy, S, Kamilar, G, Kilgore, K, Lee, P, Loi, CM, Lou, Z, Morris, M, Philippe, L, Przybranowski, S, Riley, F, Samas, B, Sanchez, B, Tecle, H, Wang, Z, Welch, K, Wilson, M & Yates, K 2007, 'N-(6,7-Dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-alkylsulfonamides as peripherally restricted N-methyl-d-aspartate receptor antagonists for the treatment of pain', Bioorganic and Medicinal Chemistry Letters, vol. 17, no. 16, pp. 4599-4603. https://doi.org/10.1016/j.bmcl.2007.05.083

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AU - Finzel, Barry

AU - Gan, Xinmin

AU - Guppy, Sheila

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AU - Kilgore, Kenneth

AU - Lee, Pil

AU - Loi, Cho Ming

AU - Lou, Zhen

AU - Morris, Mark

AU - Philippe, Laurence

AU - Przybranowski, Sally

AU - Riley, Frank

AU - Samas, Brian

AU - Sanchez, Brian

AU - Tecle, Haile

AU - Wang, Ziqiang

AU - Welch, Kathryn

AU - Wilson, Michael

AU - Yates, Karen

PY - 2007/8/15

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ER -

N-(6,7-Dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-alkylsulfonamides as peripherally restricted N-methyl-d-aspartate receptor antagonists for the treatment of pain

Abstract

Keywords

UN SDGs

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