Myricetin inhibits UVB-induced angiogenesis by regulating PI-3 kinase in vivo

Sung Keun Jung, Ki Won Lee, Sanguine Byun, Eun Jung Lee, Jong Eun Kim, Ann M. Bode, Zigang Dong, Hyong Joo Lee

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52 Scopus citations

Abstract

Myricetin is one of the principal phytochemicals in onions, berries and red wine. Previous studies showed that myricetin exhibits potent anticancer and chemopreventive effects. The present study examined the effect of myricetin on ultraviolet (UV) B-induced angiogenesis in an SKH-1 hairless mouse skin tumorigenesis model. Topical treatment with myricetin inhibited repetitive UVB-induced neovascularization in SKH-1 hairless mouse skin. The induction of vascular endothelial growth factor, matrix metalloproteinase (MMP)-9 and MMP-13 expression by chronic UVB irradiation was significantly suppressed by myricetin treatment. Immunohistochemical and western blot analyses revealed that myricetin inhibited UVB-induced hypoxia inducible factor-1α expression in mouse skin. Western blot analysis and kinase assay data revealed that myricetin suppressed UVB-induced phosphatidylinositol-3 (PI-3) kinase activity and subsequently attenuated the UVB-induced phosphorylation of Akt/p70S6K in mouse skin lysates. A pull-down assay revealed the direct binding of PI-3 kinase and myricetin in mouse skin lysates. Our results indicate that myricetin suppresses UVB-induced angiogenesis by regulating PI-3 kinase activity in vivo in mouse skin.

Original languageEnglish (US)
Pages (from-to)911-917
Number of pages7
JournalCarcinogenesis
Volume31
Issue number5
DOIs
StatePublished - Dec 11 2009

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    Jung, S. K., Lee, K. W., Byun, S., Lee, E. J., Kim, J. E., Bode, A. M., Dong, Z., & Lee, H. J. (2009). Myricetin inhibits UVB-induced angiogenesis by regulating PI-3 kinase in vivo. Carcinogenesis, 31(5), 911-917. https://doi.org/10.1093/carcin/bgp221