Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the phosphatidylinositol 3-kinase (PI3K) signaling pathway

P. A. Phillips; V. Sangwan; D. Borja-Cacho; V. Dudeja; S. M. Vickers; A. K. Saluja

doi:10.1016/j.canlet.2011.05.002

Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the phosphatidylinositol 3-kinase (PI3K) signaling pathway

P. A. Phillips
, V. Sangwan
, D. Borja-Cacho
, V. Dudeja
, S. M. Vickers
, A. K. Saluja

Surgery

Research output: Contribution to journal › Article › peer-review

149 Scopus citations

Abstract

Pancreatic cancer is the fourth leading cause of cancer related deaths and is a disease with poor prognosis. It is refractory to standard chemotherapeutic drugs or to novel treatment modalities, making it imperative to find new treatments. In this study, using both primary and metastatic pancreatic cancer cell lines, we have demonstrated that the flavonoid myricetin induced pancreatic cancer cell death in vitro via apoptosis, and caused a decrease in PI3 kinase activity. In vivo, treatment of orthotopic pancreatic tumors with myricetin resulted in tumor regression and decreased metastatic spread. Importantly, myricetin was non-toxic, both in vitro and in vivo, underscoring its use as a therapeutic agent against pancreatic cancer.

Original language	English (US)
Pages (from-to)	181-188
Number of pages	8
Journal	Cancer Letters
Volume	308
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2011.05.002
State	Published - Sep 28 2011

Bibliographical note

Funding Information:
This study was supported in part from an NIH grants DK-58694 and CA-124723 (AKS). P.A.P. is currently supported by a Cancer Institute NSW Fellowship (2009–2012).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Apoptosis
Myricetin
Orthotopic model
Pancreatic cancer

Publisher link

10.1016/j.canlet.2011.05.002

Find It

Find It at U of M Libraries

Cite this

@article{5ecf9427d76c42379f52698d0ef023f1,

title = "Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the phosphatidylinositol 3-kinase (PI3K) signaling pathway",

abstract = "Pancreatic cancer is the fourth leading cause of cancer related deaths and is a disease with poor prognosis. It is refractory to standard chemotherapeutic drugs or to novel treatment modalities, making it imperative to find new treatments. In this study, using both primary and metastatic pancreatic cancer cell lines, we have demonstrated that the flavonoid myricetin induced pancreatic cancer cell death in vitro via apoptosis, and caused a decrease in PI3 kinase activity. In vivo, treatment of orthotopic pancreatic tumors with myricetin resulted in tumor regression and decreased metastatic spread. Importantly, myricetin was non-toxic, both in vitro and in vivo, underscoring its use as a therapeutic agent against pancreatic cancer.",

keywords = "Apoptosis, Myricetin, Orthotopic model, Pancreatic cancer",

author = "Phillips, \{P. A.\} and V. Sangwan and D. Borja-Cacho and V. Dudeja and Vickers, \{S. M.\} and Saluja, \{A. K.\}",

note = "Funding Information: This study was supported in part from an NIH grants DK-58694 and CA-124723 (AKS). P.A.P. is currently supported by a Cancer Institute NSW Fellowship (2009–2012).",

year = "2011",

month = sep,

day = "28",

doi = "10.1016/j.canlet.2011.05.002",

language = "English (US)",

volume = "308",

pages = "181--188",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the phosphatidylinositol 3-kinase (PI3K) signaling pathway

AU - Phillips, P. A.

AU - Sangwan, V.

AU - Borja-Cacho, D.

AU - Dudeja, V.

AU - Vickers, S. M.

AU - Saluja, A. K.

N1 - Funding Information: This study was supported in part from an NIH grants DK-58694 and CA-124723 (AKS). P.A.P. is currently supported by a Cancer Institute NSW Fellowship (2009–2012).

PY - 2011/9/28

Y1 - 2011/9/28

N2 - Pancreatic cancer is the fourth leading cause of cancer related deaths and is a disease with poor prognosis. It is refractory to standard chemotherapeutic drugs or to novel treatment modalities, making it imperative to find new treatments. In this study, using both primary and metastatic pancreatic cancer cell lines, we have demonstrated that the flavonoid myricetin induced pancreatic cancer cell death in vitro via apoptosis, and caused a decrease in PI3 kinase activity. In vivo, treatment of orthotopic pancreatic tumors with myricetin resulted in tumor regression and decreased metastatic spread. Importantly, myricetin was non-toxic, both in vitro and in vivo, underscoring its use as a therapeutic agent against pancreatic cancer.

AB - Pancreatic cancer is the fourth leading cause of cancer related deaths and is a disease with poor prognosis. It is refractory to standard chemotherapeutic drugs or to novel treatment modalities, making it imperative to find new treatments. In this study, using both primary and metastatic pancreatic cancer cell lines, we have demonstrated that the flavonoid myricetin induced pancreatic cancer cell death in vitro via apoptosis, and caused a decrease in PI3 kinase activity. In vivo, treatment of orthotopic pancreatic tumors with myricetin resulted in tumor regression and decreased metastatic spread. Importantly, myricetin was non-toxic, both in vitro and in vivo, underscoring its use as a therapeutic agent against pancreatic cancer.

KW - Apoptosis

KW - Myricetin

KW - Orthotopic model

KW - Pancreatic cancer

UR - https://www.scopus.com/pages/publications/79959564406

UR - https://www.scopus.com/pages/publications/79959564406#tab=citedBy

U2 - 10.1016/j.canlet.2011.05.002

DO - 10.1016/j.canlet.2011.05.002

M3 - Article

C2 - 21676539

AN - SCOPUS:79959564406

SN - 0304-3835

VL - 308

SP - 181

EP - 188

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the phosphatidylinositol 3-kinase (PI3K) signaling pathway

Abstract

Bibliographical note

UN SDGs

Keywords

Publisher link

Find It

Other files and links

Fingerprint

Cite this