Myogenic progenitor specification from pluripotent stem cells

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Pluripotent stem cells represent important tools for both basic and translational science as they enable to study mechanisms of development, model diseases in vitro and provide a potential source of tissue-specific progenitors for cell therapy. Concomitantly with the increasing knowledge of the molecular mechanisms behind activation of the skeletal myogenic program during embryonic development, novel findings in the stem cell field provided the opportunity to begin recapitulating in vitro the events occurring during specification of the myogenic lineage. In this review, we will provide a perspective of the molecular mechanisms responsible for skeletal myogenic commitment in the embryo and how this knowledge was instrumental for specifying this lineage from pluripotent stem cells. In addition, we will discuss the current limitations for properly recapitulating skeletal myogenesis in the petri dish, and we will provide insights about future applications of pluripotent stem cell-derived myogenic cells.

Original languageEnglish (US)
Pages (from-to)87-98
Number of pages12
JournalSeminars in Cell and Developmental Biology
Volume72
DOIs
StatePublished - Dec 2017

Bibliographical note

Funding Information:
We thank all the investigators in the skeletal muscle and developmental biology fields for their important contributions and, we apologize for those reports that were not included in this review due to space limitations. RCRP is supported by NIH grants R01 AR055299 and R01 AR071439, the Greg Marzolf Jr Foundation, ADVault, Inc and MyDirectives.com. AM thanks the support from Regenerative Medicine Minnesota.

Publisher Copyright:
© 2017 Elsevier Ltd

Keywords

  • BMP inhibitor
  • Cell therapy
  • Disease modeling
  • ES cells
  • GSK3 inhibitor
  • Mesoderm specification
  • Muscle development
  • Muscle regeneration
  • Myf5
  • MyoD
  • Myogenesis
  • Myogenic progenitor
  • Paraxial mesoderm
  • Pax3
  • Pax7
  • Pluripotent stem cells
  • Somite
  • TGFβ inhibitor
  • WNT activation
  • iPS cells

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