Myocardial injury in acute stroke: A troponin I study

Julio A. Chalela, Mustapha A. Ezzeddine, Lisa Davis, Steven Warach

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57 Scopus citations


Introduction: Acute cerebrovascular insults can induce a variety of cardiac changes. We sought to describe the findings in a cohort of patients who had an acute stroke in whom Troponin I (TI) was sampled to determine the presence of associated myocardial damage. Materials and Methods: This is a retrospective case series study. The investigators identified all patients who had an acute stroke in whom TI had been sampled. Demographics, stroke severity as determined by National Institutes of Health Stroke Scale (NIHSS), stroke location, electrocardiogram (EKG) results, echocardiography results, and cardiology evaluation were obtained from the stroke database or the medical records. Logistic regression analysis was performed to determine the clinical and paraclinical variables associated with TI elevation. Results: During a 14-month period, 191 patients were studied, but TI levels were available in only 160 (84%) of the 191 patients. The sample was composed of 89 (55%) men and 71 (45%) women, with a median age of 76 years. Elevated TI occurred in 10 (6%) of the 160 patients. EKG changes suggestive of cardiac ischemia occurred in 2 of the 10 patients with high TI who had a stroke. In the remainder patients' TI elevations occurred in the absence of EKG or echocardiographic abnormalities. High NIHSS but no other variable was associated with TI elevation (p = .02). Ventricular arrhythmias, congestive heart failure, post-infarct pericarditis, and sudden death did not occur. Conclusion: In this limited sample, elevated TI occurred in 6% of the patients with acute stroke and was associated with severe stroke. Although in some patients who have acute stroke, TI elevation may represent coronary ischemia, in others it may reflect neurogenic-induced cardiac injury.

Original languageEnglish (US)
Pages (from-to)343-346
Number of pages4
JournalNeurocritical Care
Issue number3
StatePublished - 2004


  • Acute stroke
  • Cardic injury
  • Stroke severity
  • Troponin


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