Myocardial injury after phenylpropanolamine ingestion

P. R. Pentel, F. L. Mikell, J. H. Zavoral

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Three patients developed clinical evidence of myocardial injury after acute ingestion of phenylpropanolamine, a sympathomimetic amine found in a large number of decongestant and appetite suppressant formulations. Increases in the serum creatine kinase and MB isoenzyme levels, ventricular arrhythmias, and electrocardiographic repolarisation abnormalities were seen. Excessive catecholamine stimulation has been shown to produce acute myocardial necrosis experimentally, and a similar mechanism may be present in these patients.

Original languageEnglish (US)
Pages (from-to)51-54
Number of pages4
JournalBritish heart journal
Issue number1
StatePublished - 1982
Externally publishedYes


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