MYO5A::FGFR1 represents a novel fusion event in pediatric low-grade glioma

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Low-grade gliomas (LGG) represent the most common type of central nervous system (CNS) neoplasm in children. Importantly, pediatric-type LGGs, affecting children and young adults, are molecularly distinct from adult-type LGGs. While the latter typically harbor IDH1 or IDH2 mutations, pediatric-type LGGs invariably involve activation of the mitogen-activated protein kinase (MAPK) cascade. While adult-type LGG often progress into higher grade gliomas over time, pediatric-type LGGs are associated with excellent overall survival of >95%. Nonetheless, they are at risk for progression many years after diagnosis and patients may suffer functional morbidity.

Original languageEnglish (US)
Article numbervdad017
JournalNeuro-Oncology Advances
Issue number1
StatePublished - Jan 1 2023

Bibliographical note

Publisher Copyright:
© The Author(s) 2023.


  • low-grade glioma
  • next generation sequencing
  • pediatric

PubMed: MeSH publication types

  • Journal Article


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