MYO5A::FGFR1 represents a novel fusion event in pediatric low-grade glioma

Robert T. Galvin; Cynthia Zheng; Garrett Fitzpatrick; Colleen L. Forster; Carolina Sandoval-Garcia; Daniel Guillaume; Ahmed Elbermawy; Andrew C. Nelson; Can Özütemiz; Liam Chen; Christopher L. Moertel

doi:10.1093/noajnl/vdad017

MYO5A::FGFR1 represents a novel fusion event in pediatric low-grade glioma

Robert T. Galvin, Cynthia Zheng, Garrett Fitzpatrick, Colleen L. Forster, Carolina Sandoval-Garcia, Daniel Guillaume, Ahmed Elbermawy, Andrew C. Nelson, Can Özütemiz, Liam Chen, Christopher L. Moertel

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1 Scopus citations

Abstract

Low-grade gliomas (LGG) represent the most common type of central nervous system (CNS) neoplasm in children. Importantly, pediatric-type LGGs, affecting children and young adults, are molecularly distinct from adult-type LGGs. While the latter typically harbor IDH1 or IDH2 mutations, pediatric-type LGGs invariably involve activation of the mitogen-activated protein kinase (MAPK) cascade. While adult-type LGG often progress into higher grade gliomas over time, pediatric-type LGGs are associated with excellent overall survival of >95%. Nonetheless, they are at risk for progression many years after diagnosis and patients may suffer functional morbidity.

Original language	English (US)
Article number	vdad017
Journal	Neuro-Oncology Advances
Volume	5
Issue number	1
DOIs	https://doi.org/10.1093/noajnl/vdad017
State	Published - Jan 1 2023

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Publisher Copyright:
© The Author(s) 2023.

Keywords

MYO5A:FGFR1
low-grade glioma
next generation sequencing
pediatric

PubMed: MeSH publication types

Journal Article

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10.1093/noajnl/vdad017

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title = "MYO5A::FGFR1 represents a novel fusion event in pediatric low-grade glioma",

abstract = "Low-grade gliomas (LGG) represent the most common type of central nervous system (CNS) neoplasm in children. Importantly, pediatric-type LGGs, affecting children and young adults, are molecularly distinct from adult-type LGGs. While the latter typically harbor IDH1 or IDH2 mutations, pediatric-type LGGs invariably involve activation of the mitogen-activated protein kinase (MAPK) cascade. While adult-type LGG often progress into higher grade gliomas over time, pediatric-type LGGs are associated with excellent overall survival of >95%. Nonetheless, they are at risk for progression many years after diagnosis and patients may suffer functional morbidity.",

keywords = "MYO5A:FGFR1, low-grade glioma, next generation sequencing, pediatric",

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doi = "10.1093/noajnl/vdad017",

language = "English (US)",

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journal = "Neuro-Oncology Advances",

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AU - Galvin, Robert T.

AU - Zheng, Cynthia

AU - Fitzpatrick, Garrett

AU - Forster, Colleen L.

AU - Sandoval-Garcia, Carolina

AU - Guillaume, Daniel

AU - Elbermawy, Ahmed

AU - Nelson, Andrew C.

AU - Özütemiz, Can

AU - Chen, Liam

AU - Moertel, Christopher L.

PY - 2023/1/1

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N2 - Low-grade gliomas (LGG) represent the most common type of central nervous system (CNS) neoplasm in children. Importantly, pediatric-type LGGs, affecting children and young adults, are molecularly distinct from adult-type LGGs. While the latter typically harbor IDH1 or IDH2 mutations, pediatric-type LGGs invariably involve activation of the mitogen-activated protein kinase (MAPK) cascade. While adult-type LGG often progress into higher grade gliomas over time, pediatric-type LGGs are associated with excellent overall survival of >95%. Nonetheless, they are at risk for progression many years after diagnosis and patients may suffer functional morbidity.

AB - Low-grade gliomas (LGG) represent the most common type of central nervous system (CNS) neoplasm in children. Importantly, pediatric-type LGGs, affecting children and young adults, are molecularly distinct from adult-type LGGs. While the latter typically harbor IDH1 or IDH2 mutations, pediatric-type LGGs invariably involve activation of the mitogen-activated protein kinase (MAPK) cascade. While adult-type LGG often progress into higher grade gliomas over time, pediatric-type LGGs are associated with excellent overall survival of >95%. Nonetheless, they are at risk for progression many years after diagnosis and patients may suffer functional morbidity.

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KW - next generation sequencing

KW - pediatric

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MYO5A::FGFR1 represents a novel fusion event in pediatric low-grade glioma

Abstract

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Keywords

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