Myeloablative versus Reduced-Intensity Hematopoietic Cell Transplantation in Myelodysplastic Syndromes: Systematic Review and Meta-analysis

Armin Rashidi, Mohamad A. Meybodi, Wenhao Cao, Haitao Chu, Erica D. Warlick, Steven Devine, Marcelo C. Pasquini, Daniel J. Weisdorf, Mehdi Hamadani

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

In a systematic review and meta-analysis, we compared allogeneic transplant outcomes after myeloablative conditioning (MAC) versus reduced-intensity conditioning (RIC) in patients with myelodysplastic syndromes. Only 2 published randomized clinical trials were found, with a pooled sample size of 183 (RIC, 92; MAC, 91). Both studies suggested an overall survival advantage after RIC, with a pooled hazard ratio (HR) of. 67 (95% confidence interval [CI],. 41 to 1.09) for RIC versus MAC. Relapse results were also concordant, with a pooled HR of 1.55 (95% CI,. 74 to 3.25) for RIC versus MAC. Neither result was statistically significant. Comparisons for other outcomes were unremarkable. In conclusion, the evidence for the optimal conditioning intensity in myelodysplastic syndromes is weak. Post-transplant maintenance strategies and incorporation of genomic information into decision-making may improve post-transplant outcomes.

Original languageEnglish (US)
Pages (from-to)e138-e141
JournalBiology of Blood and Marrow Transplantation
Volume26
Issue number6
DOIs
StatePublished - Jun 2020

Keywords

  • Meta-analysis
  • Myeloablative
  • Myelodysplastic syndromes
  • Reduced intensity
  • Transplantation

PubMed: MeSH publication types

  • Journal Article

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