Mycosis fungoides: developments in incidence, treatment and survival

A. E. Kaufman, K. Patel, K. Goyal, D. O'Leary, N. Rubin, D. Pearson, K. Bohjanen, A. Goyal

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

BACKGROUND: Prior studies have demonstrated improved disease-specific survival of mycosis fungoides (MF) patients over the last 50 years.

OBJECTIVE: To analyse patterns of survival and incidence from 1973 to 2016 and determine whether apparent improvements in MF-specific survival are due to lead-time bias rather than improvements in treatment.

METHODS: We performed an analysis of 10 155 patients diagnosed with MF from 1973 to 2016 in the United States cancer registries of SEER-18. We also performed a literature review of papers including stage data for unselected populations of MF patients prior to 2000.

RESULTS: Incidence of MF increased from 3.0 per million person-years in the 1970s to 5.9 in the 2010s. For all cohorts, non-Hodgkin lymphoma (including MF) was the leading cause of death. Survival analysis demonstrated marked improvement in disease-specific and overall survival from the 1970s to 2010s. Based on systematic review of the literature, 32%-73% of patients diagnosed prior to 2000 were diagnosed with early-stage disease, as opposed to 81% of patients in the SEER 2000-2016 cohort (P < 0.035 for all cohorts).

CONCLUSIONS: Although there have been improvements in MF-related survival over the last 50 years, these may reflect improvements in our ability to diagnose early-stage disease rather than improved treatment.

Original languageEnglish (US)
Pages (from-to)2288-2294
Number of pages7
JournalJournal of the European Academy of Dermatology and Venereology
Volume34
Issue number10
DOIs
StatePublished - Oct 1 2020

Bibliographical note

Publisher Copyright:
© 2020 European Academy of Dermatology and Venereology

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