Mutational effects depend on ploidy level: All else is not equal

Aleeza C. Gerstein

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Ploidy is predicted to influence adaptation directly, yet whether single mutations behave the same in different ploidy backgrounds has not been well studied. It has often been assumed theoretically that aside from dominance, selective parameters do not differ between cells of varying ploidy. Using the budding yeast Saccharomyces cerevisiae, I compared the effect size of 20 adaptive mutations in haploids and homozygous diploids and found, surprisingly, that the same mutations often had a much larger effect in haploids than homozygous diploids. This empirical result demonstrates that it cannot be assumed that mutations will have the same effect in haploids and homozygous diploids.

Original languageEnglish (US)
Article number20120614
JournalBiology letters
Issue number1
StatePublished - Feb 23 2013
Externally publishedYes


  • Dose-response
  • Effect size
  • Fitness
  • Growth rate


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