Mutation of hepatocyte nuclear factor-1β inhibits Pkhd1 gene expression and produces renal cysts in mice

Keyphrases

• Gene Expression 100%
• HNF1A 100%
• Renal Cyst 100%
• PKHD1 100%
• Kidney 33%
• Maturity-onset Diabetes of the Young type 5 33%
• Autosomal Dominant Polycystic Kidney Disease (ADPKD) 22%
• Dominant Negative 22%
• Transgenic Mice 11%
• Transcription Factor 11%
• Liver 11%
• Disease Genes 11%
• Cyst 11%
• Renal Failure 11%
• OCT1 11%
• Homeodomain 11%
• Gene Transcription 11%
• Tissue-specific Gene Expression 11%
• Promoter Activity 11%
• DNase 11%
• Proximal Promoter 11%
• Cell Lining 11%
• Specific Promoter 11%
• Cystic Disease 11%
• HNF1 11%
• UNC-86 11%
• PKHD1 Gene 11%
• Evolutionarily Conserved 11%
• Hepatocyte nuclear Factor 1 Binding Site 11%
• Autosomal Dominant mutation 11%

Medicine and Dentistry

• Gene Expression 100%
• Hepatocyte Nuclear Factor 1 100%
• Renal Cyst 100%
• Promoter Region 36%
• Maturity Onset Diabetes of the Young 27%
• Polycystic Kidney Disease 18%
• Autosomal Recessive Inheritance 18%
• Diseases 18%
• Morphology 9%
• Transgenic Mouse 9%
• Hypersensitivity 9%
• Renal Failure 9%
• Transcription Factor Pit 1 9%
• Genetic Transcription 9%
• Autosomal Dominant Inheritance 9%
• Transcription Factors 9%
• Binding Site 9%
• Deoxyribonuclease 9%

Biochemistry, Genetics and Molecular Biology

• Gene Expression 100%
• Hepatocyte Nuclear Factor 1 100%
• Promoter Region 36%
• Autosomal Recessive Inheritance 18%
• Transcription 9%
• Homeodomain 9%
• Morphology 9%
• Transgenic Mouse 9%
• Binding Site 9%
• Pituitary-Specific Positive Transcription Factor 1 9%
• Genetic Transcription 9%
• Autosomal Dominant Inheritance 9%
• Transcription Factors 9%
• Erethism 9%
• Deoxyribonuclease 9%