Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster

J. C. Eissenberg, T. C. James, D. M. Foster-Hartnett, T. Hartnett, V. Ngan, S. C.R. Elgin

Research output: Contribution to journalArticlepeer-review

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Abstract

We report here that a point mutation in the gene which encodes the heterochromatin-specific nonhistone chromosomal protein HP-1 in Drosophila melanogaster is associated with dominant suppression of position-effect variegation. The mutation, a G-to-A transition at the first nucleotide of the last intron, causes missplicing of the HP-1 mRNA. This suggests that heterochromatin-specific proteins play a central role in the gene suppression associated with heterochromatic position effects.

Original languageEnglish (US)
Pages (from-to)9923-9927
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume87
Issue number24
DOIs
StatePublished - 1990

Keywords

  • aberrant pre-mRNA splicing
  • dominant suppression of heterochromatic position effects
  • heterochromatin-associated protein

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