Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster

J. C. Eissenberg; T. C. James; D. M. Foster-Hartnett; T. Hartnett; V. Ngan; S. C.R. Elgin

doi:10.1073/pnas.87.24.9923

Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster

J. C. Eissenberg, T. C. James, D. M. Foster-Hartnett, T. Hartnett, V. Ngan, S. C.R. Elgin

Research output: Contribution to journal › Article › peer-review

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Abstract

We report here that a point mutation in the gene which encodes the heterochromatin-specific nonhistone chromosomal protein HP-1 in Drosophila melanogaster is associated with dominant suppression of position-effect variegation. The mutation, a G-to-A transition at the first nucleotide of the last intron, causes missplicing of the HP-1 mRNA. This suggests that heterochromatin-specific proteins play a central role in the gene suppression associated with heterochromatic position effects.

Original language	English (US)
Pages (from-to)	9923-9927
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	87
Issue number	24
DOIs	https://doi.org/10.1073/pnas.87.24.9923
State	Published - 1990
Externally published	Yes

Keywords

aberrant pre-mRNA splicing
dominant suppression of heterochromatic position effects
heterochromatin-associated protein

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10.1073/pnas.87.24.9923

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Eissenberg, J. C., James, T. C., Foster-Hartnett, D. M., Hartnett, T., Ngan, V., & Elgin, S. C. R. (1990). Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America, 87(24), 9923-9927. https://doi.org/10.1073/pnas.87.24.9923

Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster. / Eissenberg, J. C.; James, T. C.; Foster-Hartnett, D. M. et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, No. 24, 1990, p. 9923-9927.

Research output: Contribution to journal › Article › peer-review

Eissenberg, JC, James, TC, Foster-Hartnett, DM, Hartnett, T, Ngan, V & Elgin, SCR 1990, 'Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster', Proceedings of the National Academy of Sciences of the United States of America, vol. 87, no. 24, pp. 9923-9927. https://doi.org/10.1073/pnas.87.24.9923

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AU - Ngan, V.

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AB - We report here that a point mutation in the gene which encodes the heterochromatin-specific nonhistone chromosomal protein HP-1 in Drosophila melanogaster is associated with dominant suppression of position-effect variegation. The mutation, a G-to-A transition at the first nucleotide of the last intron, causes missplicing of the HP-1 mRNA. This suggests that heterochromatin-specific proteins play a central role in the gene suppression associated with heterochromatic position effects.

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Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster

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