Mutant prevention concentrations of ABT-492, levofloxacin, moxifloxacin, and gatifloxacin against three common respiratory pathogens

Elizabeth D. Hermsen; Laurie B. Hovde; George N. Konstantinides; John C. Rotschafer

doi:10.1128/AAC.49.4.1633-1635.2005

Mutant prevention concentrations of ABT-492, levofloxacin, moxifloxacin, and gatifloxacin against three common respiratory pathogens

Elizabeth D. Hermsen
, Laurie B. Hovde
, George N. Konstantinides
, John C. Rotschafer

Experimental and Clinical Pharmacology

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The purpose of this study was to compare the mutant prevention concentration (MPC) of ABT-492 to those of levofloxacin, moxifloxacin, and gatifloxacin against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. The fluoroquinolones had comparable mutation selection windows, which is the ratio of MPC/MIC, for all isolates.

Original language	English (US)
Pages (from-to)	1633-1635
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	49
Issue number	4
DOIs	https://doi.org/10.1128/AAC.49.4.1633-1635.2005
State	Published - Apr 2005

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SDG 3 Good Health and Well-being

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AU - Konstantinides, George N.

AU - Rotschafer, John C.

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AB - The purpose of this study was to compare the mutant prevention concentration (MPC) of ABT-492 to those of levofloxacin, moxifloxacin, and gatifloxacin against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. The fluoroquinolones had comparable mutation selection windows, which is the ratio of MPC/MIC, for all isolates.

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ER -

Mutant prevention concentrations of ABT-492, levofloxacin, moxifloxacin, and gatifloxacin against three common respiratory pathogens

Abstract

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