Muscle strength following direct injection of doxorubicin into rabbit sternocleidomastoid muscle in situ

Jon H. Falkenberg, Paul A. Iaizzo, Linda K. McLoon

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Direct intramuscular injection of doxorubicin results in permanent myofiber loss. A previous phase I trial demonstrated that such injections could successfully treat blepharospasm and hemifacial spasm. Our previous in vitro study demonstrated that doxorubicin resulted in a dose-dependent reduction in isometric force generation in sternocleidomastoid muscle in rabbits. This present study examined alterations in force generation in these treated muscles in situ, i.e., with the blood and nerve supply intact. Two months after a single doxorubicin injection, functional changes in peak twitch, tetanic force generation, and fatigue rate were assessed in control and doxorubicin-treated sternocleidomastoid muscles in rabbits. Peak force measurements were reduced in the treated muscles. These reductions in muscle strength were significantly greater at tetanic peak amplitudes. Fatigue rate was not altered by doxorubicin treatment of the sternocleidomastoid muscles. These findings support the potential clinical use of doxorubicin chemomyectomy for the treatment of patients with cervical dystonia.

Original languageEnglish (US)
Pages (from-to)735-741
Number of pages7
JournalMuscle and Nerve
Volume25
Issue number5
DOIs
StatePublished - May 13 2002

Keywords

  • Cervical muscles
  • Doxorubicin
  • Force assessment
  • Myotoxin
  • Skeletal muscle

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