TY - JOUR
T1 - Muscle disuse
T2 - Adaptation of antioxidant systems is age dependent
AU - Chen, Chiao Nan
AU - Brown-Borg, Holly M.
AU - Rakoczy, Sharlene G.
AU - Thompson, LaDora V.
PY - 2008/5
Y1 - 2008/5
N2 - This study investigated the age effect on antioxidant adaptation to muscle disuse. Adult and old rats were randomized into 4 groups: weight bearing (control), 3 days of hind-limb unloading (HU), 7 days of HU, and 14 days of HU. Activities of Cu-Zn superoxide dismutase (SOD), catalase, and glutathione (GSH), as well as GSH peroxidase levels were measured in the soleus. Neither disuse nor aging changed the activity of Cu-Zn SOD. The old rats had greater GSH peroxidase activity, whereas the activity of catalase had a compensatory increase with disuse, independent of age. Reduced GSH level and total glutathione (tGSH) level had age-related change with disuse. In old rats, the GSH and tGSH levels were lower with disuse, whereas the levels remained stable with disuse in adult rats. The depletion of intracellular GSH and tGSH levels of muscles from aged animals with disuse may make aged muscles more susceptible to oxidative damage.
AB - This study investigated the age effect on antioxidant adaptation to muscle disuse. Adult and old rats were randomized into 4 groups: weight bearing (control), 3 days of hind-limb unloading (HU), 7 days of HU, and 14 days of HU. Activities of Cu-Zn superoxide dismutase (SOD), catalase, and glutathione (GSH), as well as GSH peroxidase levels were measured in the soleus. Neither disuse nor aging changed the activity of Cu-Zn SOD. The old rats had greater GSH peroxidase activity, whereas the activity of catalase had a compensatory increase with disuse, independent of age. Reduced GSH level and total glutathione (tGSH) level had age-related change with disuse. In old rats, the GSH and tGSH levels were lower with disuse, whereas the levels remained stable with disuse in adult rats. The depletion of intracellular GSH and tGSH levels of muscles from aged animals with disuse may make aged muscles more susceptible to oxidative damage.
KW - Aging
KW - Antioxidant
KW - Disuse
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U2 - 10.1093/gerona/63.5.461
DO - 10.1093/gerona/63.5.461
M3 - Article
C2 - 18511748
AN - SCOPUS:47049127017
SN - 1079-5006
VL - 63
SP - 461
EP - 466
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 5
ER -