Muscle-derived myoglianin regulates drosophila imaginal disc growth

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3 Scopus citations

Abstract

Organ growth and size are finely tuned by intrinsic and extrinsic signaling molecules. In Drosophila, the BMP family member Dpp is produced in a limited set of imaginal disc cells and functions as a classic morphogen to regulate pattern and growth by diffusing throughout imaginal discs. However, the role of TGFb/Activin-like ligands in disc growth control remains ill-defined. Here, we demonstrate that Myoglianin (Myo), an Activin family member, and a close homolog of mammalian Myostatin (Mstn), is a muscle-derived extrinsic factor that uses canonical dSmad2-mediated signaling to regulate wing size. We propose that Myo is a myokine that helps mediate an allometric relationship between muscles and their associated appendages.

Original languageEnglish (US)
Article numbere51710
Pages (from-to)1-22
Number of pages22
JournaleLife
Volume9
DOIs
StatePublished - Jul 2020

Bibliographical note

Publisher Copyright:
© Upadhyay et al.

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural

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