Muscimol induces gastric acid secretion after central administration

Allen S. Levine, John E. Morley, Julie Kneip, Martha Grace, Stephen E. Silvis

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Intracerebroventricular administration of the GABA agonist, muscimol, resulted in a dose-dependent increase in gastric acid secretion in pylorus ligated rats. The maximum increase in gastric acid secretion occured in the second hour. The GABA antagonist, bicuculline methiodide, reversed the muscimol effect on gastric acid secretion. Intracerebroventricular administration of d-alanine methionine enkephalin, bombesin and calcitonin significantly suppressed the muscimol-induced gastric accretion. The present study suggests that the GABAergic system plays a role in the central control of gastric acid secretion.

Original languageEnglish (US)
Pages (from-to)270-274
Number of pages5
JournalBrain Research
Volume229
Issue number1
DOIs
StatePublished - Dec 14 1981

Keywords

  • GABA
  • bombesin
  • calcitonin
  • enkephalin
  • gamma amino butyric acid
  • gastric acid
  • muscimol

Fingerprint Dive into the research topics of 'Muscimol induces gastric acid secretion after central administration'. Together they form a unique fingerprint.

  • Cite this