Muscimol induces gastric acid secretion after central administration

Allen S. Levine, John E. Morley, Julie Kneip, Martha Grace, Stephen E. Silvis

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Intracerebroventricular administration of the GABA agonist, muscimol, resulted in a dose-dependent increase in gastric acid secretion in pylorus ligated rats. The maximum increase in gastric acid secretion occured in the second hour. The GABA antagonist, bicuculline methiodide, reversed the muscimol effect on gastric acid secretion. Intracerebroventricular administration of d-alanine methionine enkephalin, bombesin and calcitonin significantly suppressed the muscimol-induced gastric accretion. The present study suggests that the GABAergic system plays a role in the central control of gastric acid secretion.

Original languageEnglish (US)
Pages (from-to)270-274
Number of pages5
JournalBrain Research
Issue number1
StatePublished - Dec 14 1981


  • GABA
  • bombesin
  • calcitonin
  • enkephalin
  • gamma amino butyric acid
  • gastric acid
  • muscimol


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