Intracerebroventricular administration of the GABA agonist, muscimol, resulted in a dose-dependent increase in gastric acid secretion in pylorus ligated rats. The maximum increase in gastric acid secretion occured in the second hour. The GABA antagonist, bicuculline methiodide, reversed the muscimol effect on gastric acid secretion. Intracerebroventricular administration of d-alanine methionine enkephalin, bombesin and calcitonin significantly suppressed the muscimol-induced gastric accretion. The present study suggests that the GABAergic system plays a role in the central control of gastric acid secretion.
- gamma amino butyric acid
- gastric acid