Muscimol induced feeding: A model to study the hypothalamic regulation of appetite

John E. Morley, Allen S. Levine, Julie Kneip

Research output: Contribution to journalArticlepeer-review

76 Scopus citations

Abstract

Intraventricular administration of the GABA agonist, muscimol, reliably induces feeding in sated rats in a dose dependent manner over a range from 50 to 500 ng. We used this pharmacological stimulant of appetite to examine the interrelationships of the peptides and monoamines involved in the hypothalamic regulation of appetite. Eating induced by muscimol (500 ng ICV) was suppressed by the opiate antagonist, naloxone; the dopamine antagonist, haloperidol; the cholinergic antagonist, atropine and by calcitonin. We could demonstrate no effect of thyrotropin releasing hormone or its metabolite histidyl-proline diketopiperazine or cholecystokinin-octapeptide, bombesin, isoproterenol, or phentolamine in doses known to suppress appetite. Based on these experimental results we propose a model of intrahypothalamic appetite regulation.

Original languageEnglish (US)
Pages (from-to)1213-1218
Number of pages6
JournalLife Sciences
Volume29
Issue number12
DOIs
StatePublished - Sep 21 1981

Fingerprint Dive into the research topics of 'Muscimol induced feeding: A model to study the hypothalamic regulation of appetite'. Together they form a unique fingerprint.

Cite this