Murine models of human colorectal cancer: Techniques and limitations

Jasneet Singh Bhullar, Vijay K. Mittal

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Murine models of colon carcinogenesis are an essential tool in understanding the mechanisms of pathogenesis and to evaluate therapeutic and preventive measures. Over the years considerable changes in the understanding of the murine models of human colon cancer has resulted in numerous models being reported in the literature. The reports of colon cancer transgenic mice were followed by human xenograft heterotopic murine models. With the orthotopic tumor models being found to be more relevant in portraying the human disease process as opposed to heterotopic models, many techniques for making orthotopic colorectal murine models were reported. Although all of these models have their advantages and limitations, the latest orthotopic murine models seem to accurately represent and replicate the human disease process. We discuss the different human colon cancer murine models, their background, the technique of creating them along with their advantages and limitations. This extensive overview and details of an array of different resources in this field offers the researchers a wide choice to choose a model which is more applicable to the type of study being planned.

Original languageEnglish (US)
Title of host publicationAnimal Models in Cancer Research and Human Disease
Subtitle of host publicationApplications, Outcomes and Controversies
PublisherNova Science Publishers, Inc.
Pages121-131
Number of pages11
ISBN (Print)9781624175879
StatePublished - Mar 1 2013

Keywords

  • Animal model
  • Animals
  • Anticarcinogenic Agents
  • Chemically induced
  • Chemopre-vention
  • Chemoprevention
  • Colon cancer
  • Colon-carcinogenesis
  • Colonic neoplasms
  • Colorectal cancer
  • Diagnostic use
  • Diet
  • Diet disease models
  • Heterotopic model
  • Mice
  • Min-mice
  • Mouse
  • Murine
  • Murine model
  • Mutant strains
  • Orthotopic model
  • Precancerous conditions
  • Prevention and control
  • Therapeutic use
  • Xenograft

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