Abstract
Selection with modified aptamers: A method is described for design of glycocluster ligands by directed evolution. Glycan azides are attached to a library of alkyne-containing DNA sequences. DNA sequences which cluster the glycans best for multivalent binding to the target are selected and amplified. This method has been applied to the development of high-mannose clusters which bind HIV-neutralizing antibody 2G12.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 11238-11242 |
| Number of pages | 5 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 50 |
| Issue number | 47 |
| DOIs | |
| State | Published - Nov 18 2011 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- carbohydrates
- cluster effect
- directed evolution
- glycoconjugates
- multivalency
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