Multiscale computation for bioartificial soft tissues with complex geometries

Xiao Juan Luo, Triantafyllos Stylianopoulos, Victor H. Barocas, Mark S. Shephard

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The mechanical function of soft collagenous tissues is inherently multiscale, with the tissue dimension being in the centimeter length scale and the underlying collagen network being in the micrometer length scale. This paper uses a volume averaging multiscale model to predict the collagen gel mechanics. The model is simulated using a multiscale component toolkit that is capable of dealing with any 3D geometries. Each scale in the multiscale model is treated as an independent component that exchanges the deformation and average stress information through a scale-linking operator. An arterial bifurcation was simulated using the multiscale model, and the results demonstrated that the mechanical response of the soft tissues is strongly sensitive to the network orientation and fiber-to-fiber interactions.

Original languageEnglish (US)
Pages (from-to)87-95
Number of pages9
JournalEngineering with Computers
Issue number1
StatePublished - 2009

Bibliographical note

Funding Information:
This work was supported by NIH grant 1 R01 EB0005813-01. T. Stylianopoulos was supported by a Doctoral Dissertation Fellowship from the University of Minnesota.


  • Collagen fiber
  • Multiscale computation
  • Tissue engineering
  • Volume averaging


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