Multiple transmissions of chromosomally integrated human herpesvirus-6 in one family

Research output: Contribution to journalArticlepeer-review

Abstract

Chromosomally integrated human herpesvirus-6 (ciHHV-6) can be transmitted from parent to child or via allogeneic hematopoietic cell transplantation (HCT). We report a case of ciHHV-6 transmitted via syngeneic HCT, and vertically across 3 generations. ciHHV-6 was transmitted from a parent to the patient and her identical twin, and from the patient to her son. The patient underwent syngeneic HCT as rescue from chemotherapy-induced aplasia during which ciHHV-6 was re-transmitted to her, this time from her identical twin. This is the first report, to our knowledge, of a patient acquiring ciHHV-6 once via germline from a parent and again via syngeneic HCT from an identical twin.

Original languageEnglish (US)
Article numbere12816
JournalTransplant Infectious Disease
Volume20
Issue number1
DOIs
StatePublished - Feb 1 2018

Keywords

  • HHV-6
  • allogeneic
  • chromosomally integrated
  • syngeneic
  • transplantation

PubMed: MeSH publication types

  • Case Reports

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