Modern transducer technology allows for the design and implementation of therapeutic arrays with relatively wide bandwidths (>50%) and low cross coupling between elements. We present results from a 3.5 MHz, 64-element prototype designed for small-animal and superficial therapeutic HIFU applications (Imasonic, Inc.) This transducer has a 58% 6-dB fractional BW average on its elements allowing for therapeutic output in the frequency range of 2.7 - 4.6 MHz. We present a simulation/experimental study to evaluate and optimize the focusing capabilities of the phased array prototype when excited by multiple-frequency components. Preliminary results have shown that multiple-frequency excitation may be beneficial in enhancing the therapeutic effects of HIFU beams. A multiple-focus pattern synthesis algorithm for arrays excited by multiple-frequency signals has been developed and tested using linear pressure field simulations. The algorithm maintains the precise phase relationship between the frequency components at each focal spot to achieve a desirable outcome. Hydrophone measurements to validate the approach show that nonlinear effects at the focal location are more prominent with the frequency mixing compared to conventional single frequency excitation. An in vitro study of lesion formation in freshly excised porcine liver was investigated.