Multimodal population brain imaging in the UK Biobank prospective epidemiological study

Karla L. Miller; Fidel Alfaro-Almagro; Neal K. Bangerter; David L. Thomas; Essa Yacoub; Junqian Xu; Andreas J. Bartsch; Saad Jbabdi; Stamatios N. Sotiropoulos; Jesper L R Andersson; Ludovica Griffanti; Gwenaëlle Douaud; Thomas W. Okell; Peter Weale; Iulius Dragonu; Steve Garratt; Sarah Hudson; Rory Collins; Mark Jenkinson; Paul M. Matthews; Stephen M. Smith

doi:10.1038/nn.4393

Multimodal population brain imaging in the UK Biobank prospective epidemiological study

Karla L. Miller, Fidel Alfaro-Almagro, Neal K. Bangerter, David L. Thomas, Essa Yacoub, Junqian Xu, Andreas J. Bartsch, Saad Jbabdi, Stamatios N. Sotiropoulos, Jesper L R Andersson, Ludovica Griffanti, Gwenaëlle Douaud, Thomas W. Okell, Peter Weale, Iulius Dragonu, Steve Garratt, Sarah Hudson, Rory Collins, Mark Jenkinson, Paul M. MatthewsStephen M. Smith

Radiology

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1057 Scopus citations

Abstract

Medical imaging has enormous potential for early disease prediction, but is impeded by the difficulty and expense of acquiring data sets before symptom onset. UK Biobank aims to address this problem directly by acquiring high-quality, consistently acquired imaging data from 100,000 predominantly healthy participants, with health outcomes being tracked over the coming decades. The brain imaging includes structural, diffusion and functional modalities. Along with body and cardiac imaging, genetics, lifestyle measures, biological phenotyping and health records, this imaging is expected to enable discovery of imaging markers of a broad range of diseases at their earliest stages, as well as provide unique insight into disease mechanisms. We describe UK Biobank brain imaging and present results derived from the first 5,000 participants' data release. Although this covers just 5% of the ultimate cohort, it has already yielded a rich range of associations between brain imaging and other measures collected by UK Biobank.

Original language	English (US)
Pages (from-to)	1523-1536
Number of pages	14
Journal	Nature neuroscience
Volume	19
Issue number	11
DOIs	https://doi.org/10.1038/nn.4393
State	Published - Oct 26 2016

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http://europepmc.org/articles/pmc5086094

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Miller, K. L., Alfaro-Almagro, F., Bangerter, N. K., Thomas, D. L., Yacoub, E., Xu, J., Bartsch, A. J., Jbabdi, S., Sotiropoulos, S. N., Andersson, J. L. R., Griffanti, L., Douaud, G., Okell, T. W., Weale, P., Dragonu, I., Garratt, S., Hudson, S., Collins, R., Jenkinson, M., ... Smith, S. M. (2016). Multimodal population brain imaging in the UK Biobank prospective epidemiological study. Nature neuroscience, 19(11), 1523-1536. https://doi.org/10.1038/nn.4393

Miller, KL, Alfaro-Almagro, F, Bangerter, NK, Thomas, DL, Yacoub, E, Xu, J, Bartsch, AJ, Jbabdi, S, Sotiropoulos, SN, Andersson, JLR, Griffanti, L, Douaud, G, Okell, TW, Weale, P, Dragonu, I, Garratt, S, Hudson, S, Collins, R, Jenkinson, M, Matthews, PM & Smith, SM 2016, 'Multimodal population brain imaging in the UK Biobank prospective epidemiological study', Nature neuroscience, vol. 19, no. 11, pp. 1523-1536. https://doi.org/10.1038/nn.4393

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Multimodal population brain imaging in the UK Biobank prospective epidemiological study

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