Multimodal MRI assessment of damage and plasticity caused by status epilepticus in the rat brain

Olli Gröhn; Alejandra Sierra; Riikka Immonen; Teemu Laitinen; Kimmo Lehtimäki; Antti Airaksinen; Nick Hayward; Jaak Nairismagi; Lauri Lehto; Asla Pitkänen

doi:10.1111/j.1528-1167.2011.03239.x

Multimodal MRI assessment of damage and plasticity caused by status epilepticus in the rat brain

Olli Gröhn, Alejandra Sierra, Riikka Immonen, Teemu Laitinen, Kimmo Lehtimäki, Antti Airaksinen, Nick Hayward, Jaak Nairismagi, Lauri Lehto, Asla Pitkänen

Radiology

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22 Scopus citations

Abstract

Status epilepticus or other brain-damaging insults launch a cascade of events that may lead to the development of epilepsy. MRI techniques available today, including T₂- and T₁-weighted imaging, functional MRI, manganese enhanced MRI (MEMRI), arterial spin labeling (ASL), diffusion tensor imaging (DTI), and phase imaging, can detect not only damage caused by status epilepticus but also plastic changes in the brain that occur in response to damage. Optimal balance between damage and recovery processes is a key for planning possible treatments, and noninvasive imaging has the potential to greatly facilitate this process and to make personalized treatment plans possible.

Original language	English (US)
Pages (from-to)	57-60
Number of pages	4
Journal	Epilepsia
Volume	52
Issue number	SUPPL. 8
DOIs	https://doi.org/10.1111/j.1528-1167.2011.03239.x
State	Published - Oct 2011

Keywords

Arterial spin labeling MRI
Diffusion MRI
Fractional anisotropy
Manganese-enhanced MRI
Neurodegeneration

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10.1111/j.1528-1167.2011.03239.x

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abstract = "Status epilepticus or other brain-damaging insults launch a cascade of events that may lead to the development of epilepsy. MRI techniques available today, including T2- and T1-weighted imaging, functional MRI, manganese enhanced MRI (MEMRI), arterial spin labeling (ASL), diffusion tensor imaging (DTI), and phase imaging, can detect not only damage caused by status epilepticus but also plastic changes in the brain that occur in response to damage. Optimal balance between damage and recovery processes is a key for planning possible treatments, and noninvasive imaging has the potential to greatly facilitate this process and to make personalized treatment plans possible.",

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AU - Gröhn, Olli

AU - Sierra, Alejandra

AU - Immonen, Riikka

AU - Laitinen, Teemu

AU - Lehtimäki, Kimmo

AU - Airaksinen, Antti

AU - Hayward, Nick

AU - Nairismagi, Jaak

AU - Lehto, Lauri

AU - Pitkänen, Asla

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KW - Diffusion MRI

KW - Fractional anisotropy

KW - Manganese-enhanced MRI

KW - Neurodegeneration

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Multimodal MRI assessment of damage and plasticity caused by status epilepticus in the rat brain

Abstract

Keywords

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