Multimodal imaging of the retina and choroid in systemic amyloidosis

C. Nathaniel Roybal, Christian J. Sanfilippo, Hossein Nazari, Janice C. Law, Swetangi Bhaleeya, Gemmy Cheung Chui Ming, Narsing A. Rao, Szilard Kiss, Anita Agarwal, Srini Vas Sadda, David Sarraf

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Purpose: To present the multimodal imaging findings of four patients with systemic amyloidosis, renal failure, and chorioretinopathy. Methods: Retrospective analysis of four patients presenting to four institutions with evidence of amyloid induced chorioretinopathy. Fundus photography, autofluorescence, and spectral domain optical coherence tomography findings were studied and are presented. Results: Four patients with biopsy-proven systemic amyloidosis demonstrated progressive chorioretinal degeneration with color fundus photography and autofluorescent imaging. With spectral domain optical coherence tomography analysis, amyloidosisinduced chorioretinopathy was characterized by a widened choriocapillaris band, choroidal infiltration, diffuse photoreceptor dysfunction, and thinning of the outer nuclear layer. Conclusion: Multimodal imaging including spectral domain optical coherence tomography analysis in eyes of patients with systemic amyloidosis shows deposition in the choroid. The deposition may cause a secondary toxic and or barrier effect resulting in diffuse retinal pigment epithelium and photoreceptor dysfunction.

Original languageEnglish (US)
Pages (from-to)339-346
Number of pages8
JournalRetinal Cases and Brief Reports
Issue number4
StatePublished - Oct 1 2015
Externally publishedYes


  • amyloid
  • choroid
  • optical coherence tomography
  • retinal degeneration
  • retinal pigment epithelium


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