Multimodal Imaging of a Culotte Bifurcation Procedure in the Left Main Coronary Artery of a Perfusion-Fixed Human Heart: Step-by-Step with Serial Micro-CT Analyses

Thomas F. Valenzuela, Paul A. Iaizzo

Research output: Contribution to journalArticlepeer-review

Abstract

Percutaneous coronary intervention can be a high-risk procedure that would benefit from optimizing device-tissue interactions between stents and coronary vessels. Using a perfusion-fixed human heart with coronary artery disease, we performed a percutaneous coronary intervention of the left main coronary artery bifurcation. This heart was perfused and multimodal imaging was utilized to view the procedure with direct visualization, fluoroscopy, and optical coherence tomography (OCT). We followed the European Bifurcation Club’s guidelines to perform a single-stent bifurcation before transitioning to a two-stent Culotte technique. After each procedural step, the heart was removed from the perfusion apparatus and transferred to a micro-CT scanner to obtain unique scans. We conducted apposition analyses of the computational 3D models from micro-CT DICOM datasets, and compared them to the results from direct visualization and commercial OCT’s Apposition Indicator software. Additional measurements of resulting coronary anatomic expansions were taken to determine the potential roles of each step in improving procedural outcomes. Graphical Abstract: Micro-CT images show stent deformation during a percutaneous coronary intervention (provisional to Culotte bifurcation procedure) in an isolated diseased human heart. [Figure not available: see fulltext.].

Original languageEnglish (US)
Pages (from-to)927-937
Number of pages11
JournalJournal of cardiovascular translational research
Volume16
Issue number4
DOIs
StatePublished - Aug 2023

Bibliographical note

Publisher Copyright:
© 2023, The Author(s).

Keywords

  • Bifurcation stenting
  • Culotte
  • Imaging
  • Left main coronary artery
  • Micro-CT
  • Percutaneous coronary intervention

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't

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