Multilocular thymic cyst (MTC) and other tumors with MTC features: Pitfalls in diagnosis

Diana M. Oramas, Cesar A. Moran

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Cystic lesions of the anterior mediastinum represent a well-known group of benign lesions that are relatively common in the general practice, namely in the pediatric age group. In the adult population, multilocular thymic cyst (MTC) plays an important role in occurrence as it presents as a cystic anterior mediastinal mass that clinically may mimic another anterior mediastinal tumor. In general, MTC is of rather unusual occurrence and its histopathological features have been well described in the literature. However, similar histopathological features may also be associated with a gamut of other tumoral conditions that although unrelated may be encountered growing along the walls of these cystic structures. Herein a presentation of the classical MTC and the classical histopathological features of such entity in association with other tumoral conditions will be discussed. It is highly important to underscore that the final interpretation of some of these tumors is based on a thorough evaluation of the cystic lesion and a reasonable sampling for histological evaluation so that the proper interpretation can be reached. Needless to say, the radiological and clinical information of the patients with cystic anterior mediastinal lesions is very important in the final analysis of these cases.

Original languageEnglish (US)
Pages (from-to)105-112
Number of pages8
JournalSeminars in Diagnostic Pathology
Issue number2
StatePublished - Mar 2022
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021


  • Germ cell tumors
  • MALT
  • Mulitilocular thymic cyst
  • Neuroendocrine carcinoma
  • Thymoma

PubMed: MeSH publication types

  • Journal Article
  • Review


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