Multifunctional deadenylase complexes diversify mRNA control

Aaron Goldstrohm, Marvin Wickens

Research output: Contribution to journalComment/debate

222 Citations (Scopus)

Abstract

Dynamic changes of the lengths of mRNA poly(A) tails are catalysed by diverse deadenylase enzymes. Modulating the length of the poly(A) tail of an mRNA is a widespread means of controlling protein production and mRNA stability. Recent insights illuminate the specialized activities, biological functions and regulation of deadenylases. We propose that the recruitment of multifunctional deadenylase complexes provides unique opportunities to control mRNAs and that the heterogeneity of the deadenylase complexes is exploited to control translation and mRNA stability.

Original languageEnglish (US)
Pages (from-to)337-344
Number of pages8
JournalNature Reviews Molecular Cell Biology
Volume9
Issue number4
DOIs
StatePublished - Apr 1 2008
Externally publishedYes

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Messenger RNA
RNA Stability
Protein Stability
Enzymes
mRNA deadenylase

Cite this

Multifunctional deadenylase complexes diversify mRNA control. / Goldstrohm, Aaron; Wickens, Marvin.

In: Nature Reviews Molecular Cell Biology, Vol. 9, No. 4, 01.04.2008, p. 337-344.

Research output: Contribution to journalComment/debate

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