Multifactorial analysis of local recurrences in rectal cancer, including DNA ploidy studies: A predictive model

Manuel R. Moran, David A. Rothenberger, Roel A. Gallo, Stanley M. Goldberg, Edwin C. James

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

DNA ploidy studies were performed in 188 patients operated on for rectal cancer. In order to define different risk groups of patients, a stepwise logistic regression was carried out in 138 patients who underwent abdominal "curative" resections. Thirtyseven variables were analyzed. Although several variables were significant, only three improved the prognostic value: (1) more than three positive lymph nodes (p=0.0007); (2) macroscopic local tumor invasion (p=0.01); and (3) DNA ploidy (p=0.03). Standardized discriminant coefficients were used to obtain a model and format for predicting local recurrences. This is the first time that a predictive model for rectal cancer, using DNA ploidy as a variable, is reported. Based on calculated discriminant values (DV), patients can be divided into three subgroups: (1) low risk for local recurrences (DV<-1.9, n=56)-local recurrences were observed in two patients (3.6%); (2) moderate risk (DV between -1.9 and -0.6, n=55)-local recurrences occurred in nine patients (16.4%); and (3) high risk (DV>-0.6, n=27)-local recurrences occurred in 14 patients (51.8%). This predictive model for local recurrences has much better prognostic value than Dukes' staging (p<0.0001).

Original languageEnglish (US)
Pages (from-to)801-805
Number of pages5
JournalWorld Journal of Surgery
Volume17
Issue number6
DOIs
StatePublished - Nov 1993

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